In recent years, technologies, therapeutic agents, and treatment concepts in urologic oncology have continued to evolve, with precision, minimally invasive treatment, and functional preservation emerging as key directions for high-quality specialty development. From 5G-enabled remote robotic surgery expanding access to high-quality medical resources, to the continued advancement of systemic therapy for prostate cancer toward earlier stages of disease, and the development of surgical techniques centered on urinary continence and sexual function preservation, urologic oncology is gradually moving beyond a sole focus on tumor control toward comprehensive management that balances long-term survival with quality of life. In this issue, Oncology Frontier · UroStream invited Professor Shangqing Ren of Sichuan Provincial People's Hospital to share insights into important advances in urologic oncology, functional preservation in prostate cancer and related technical approaches, as well as the clinical and research development pathways for young urologists, providing practical experience and perspectives on innovation in urologic care and the development of the next generation of specialists.

High-risk and locally advanced prostate cancer is characterized by substantial biological heterogeneity, with significant differences in recurrence risk, metastatic potential, and treatment response among patients, making it a major challenge in clinical practice. With the development of novel androgen receptor pathway inhibitors, PSMA PET/CT, multi-omics technologies, and artificial intelligence, overcoming the limitations of traditional risk stratification, accurately identifying patients at truly extremely high risk, and integrating local and systemic therapies to improve long-term outcomes have become important areas of research. Oncology Frontier · UroStream invited Professor Mo Zhang of the Department of Urology, First Hospital of China Medical University, for an in-depth interview on the institution's single-center experience, precision stratification strategies, and future research directions in high-risk and locally advanced prostate cancer.

In recent years, the treatment paradigm for advanced prostate cancer has undergone a profound transformation, shifting from conventional empiric treatment toward precision stratification. With the increasing availability of genetic testing and the emergence of novel targeted therapies, individualized treatment based on molecular characteristics has become an important direction in clinical practice. Oncology Frontier · UroStream invited Professor Xiaojie Bian of Fudan University Shanghai Cancer Center for an in-depth interview on treatment decisions guided by genetic testing, individualized treatment strategies, and potential future breakthroughs.

For patients with kidney cancer who undergo radical surgery, reducing the risk of postoperative recurrence, prolonging disease-free survival, and ultimately improving overall survival have long remained key clinical priorities. In recent years, postoperative adjuvant therapy for kidney cancer has evolved from investigations of targeted therapies to breakthroughs with immunotherapy and, more recently, combinations of immunotherapy with novel targeted agents. However, because adjuvant therapy is administered to patients with no radiographically evident disease, accurately identifying microscopic residual disease, selecting patients most likely to benefit, and balancing efficacy against toxicity remain major challenges in clinical practice. Oncology Frontier · UroStream invited Professor Liangyou Gu of the Chinese PLA General Hospital for an in-depth interview to discuss major advances in postoperative adjuvant therapy for kidney cancer, strategies for identifying patients most likely to benefit, and future directions in the field.

Breast cancer surgery is undergoing a profound transformation, shifting from “maximum tolerable surgery” toward “minimum effective treatment.” How to precisely “do less” while maintaining oncologic efficacy, and how to redefine the role of surgery throughout the disease course, have become major topics of clinical discussion. Recently, at the 2026 Lingnan Breast Cancer Academic Forum, Oncology Frontier interviewed Prof. Liang Huang of Fudan University Shanghai Cancer Center. Drawing on his extensive clinical experience, Prof. Huang shared his insights into individualized surgical decision-making, the evidence supporting axillary de-escalation strategies, and the transformation of surgeons into “whole-course disease managers,” offering practical perspectives on balancing established principles with innovation in breast cancer surgery in the era of precision medicine.

Breast cancer is a malignancy that poses a serious threat to women's health worldwide. Establishing a whole-life-cycle management system covering prevention, screening, diagnosis, treatment, and rehabilitation has become a key consensus and development direction in the global breast health community. Recently, the 23rd World Breast Health Congress was held in Tianjin from May 8 to 10, 2026. During the meeting, Oncology Frontier interviewed Prof. Jin Zhang of Tianjin Medical University Cancer Institute and Hospital, who provided an in-depth interpretation of China's overall progress in breast cancer prevention and control, the achievements of Tianjin Medical University Cancer Institute and Hospital, and the significance of this international academic exchange.

Breast cancer is one of the most common malignancies affecting women worldwide. With the widespread adoption of early screening and diagnosis and continued advances in comprehensive treatment, survival rates among patients with breast cancer have improved significantly. As a result, the need for postoperative quality of life and physical and psychological rehabilitation has become increasingly important. Recently, the 23rd World Breast Health Congress was held in Tianjin from May 8 to 10, 2026. During the congress, Oncology Frontier interviewed Prof. Jian Yin of Tianjin Medical University Cancer Institute and Hospital, who provided a systematic overview of the current adoption and standardization of breast reconstruction techniques in China, key technical challenges and future directions, China's advances in integrating oncologic safety with functional and aesthetic outcomes, and the pathway for Chinese breast reconstruction techniques to reach the international stage and contribute Chinese solutions to patients worldwide.