Prostate cancer is one of the most common malignant tumors of the male genitourinary system in China. Among these patients, metastatic hormone-sensitive prostate cancer (mHSPC) carries a particularly poor prognosis and remains a major clinical challenge. In recent years, novel hormonal therapies (NHTs), represented by enzalutamide, have continuously reshaped the treatment landscape of mHSPC. With the release of long-term follow-up data from landmark studies such as ARCHES and ENZAMET, the combination of enzalutamide plus androgen deprivation therapy (ADT) has demonstrated durable survival benefits across a broad range of subgroups, including high- and low-volume disease, synchronous and metachronous metastases, and patients treated before or after chemotherapy.