When All Seems Lost? — Rethinking the Optimal Treatment Sequence for Comprehensive Management of Advanced Renal Cell Carcinoma

When All Seems Lost? — Rethinking the Optimal Treatment Sequence for Comprehensive Management of Advanced Renal Cell Carcinoma

With the advent of immune checkpoint inhibitors, advanced renal cell carcinoma (RCC) has gradually entered the “immunotherapy era.” Targeted therapy plus immunotherapy (IO+TKI) combinations are now recommended by major guidelines and have become part of the first-line treatment landscape for advanced RCC. Although head-to-head trials have unequivocally demonstrated the superiority of first-line IO+TKI combinations over TKI monotherapy, “superior” in the first line does not necessarily mean “optimal” across the entire treatment journey.
Professor Shaogang Wang: Technological Innovation Enabling Precision Minimally Invasive Surgery, with Clinical Research Driving the Future of Urology

Professor Shaogang Wang: Technological Innovation Enabling Precision Minimally Invasive Surgery, with Clinical Research Driving the Future of Urology

In recent years, urology has entered an important period of rapid technological iteration and continuous evolution in treatment concepts. From the accelerated development of advanced domestically manufactured medical equipment to the growing integration of robotic-assisted surgery, molecular imaging, and artificial intelligence into clinical practice, urology is moving toward increasingly minimally invasive, precise, and function-preserving approaches. At the same time, high-quality clinical research has become an important foundation for updating treatment standards and strengthening China's academic influence in urology. Oncology Frontier – UroStream invited Professor Shaogang Wang of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, for an in-depth interview. He shared his perspectives on trends in urological development, the clinical value and technological advances of robotic-assisted surgery, and strategies for conducting high-quality clinical research.
Pujiang Prostate Cancer Academic Conference丨Professor Xiao Lin Lu: In-Depth Interpretation of 2026 ASCO GU — Diverse Innovative Therapies Reshape the Treatment Landscape of Advanced Prostate Cancer

Pujiang Prostate Cancer Academic Conference丨Professor Xiao Lin Lu: In-Depth Interpretation of 2026 ASCO GU — Diverse Innovative Therapies Reshape the Treatment Landscape of Advanced Prostate Cancer

The Pujiang Prostate Cancer Academic Conference was held in Shanghai on June 26–27, 2026. In recent years, the development of multiple innovative therapeutic approaches—including radioligand therapy, antibody-drug conjugates (ADCs), bispecific antibodies, and PARP inhibitors—has accelerated rapidly. A series of clinical studies has opened new treatment pathways for patients with metastatic castration-resistant prostate cancer (mCRPC) and metastatic hormone-sensitive prostate cancer (mHSPC). To systematically review the evolving landscape of prostate cancer treatment, Oncology Frontier – UroStream invited Professor Xiao Lin Lu of Fudan University Shanghai Cancer Center to share his insights.
Pujiang Prostate Cancer Academic Conference | Prof. Fangning Wan: Innovations in Local Therapy, Advances in Systemic Treatment, and Clinical Applications of Cryotherapy for Prostate Cancer

Pujiang Prostate Cancer Academic Conference | Prof. Fangning Wan: Innovations in Local Therapy, Advances in Systemic Treatment, and Clinical Applications of Cryotherapy for Prostate Cancer

The 2026 Pujiang Prostate Cancer Academic Conference was held in Shanghai from June 26–27, 2026. As treatment strategies for prostate cancer continue to evolve, local therapy has progressed beyond conventional radical surgery toward robot-assisted precision surgery with greater emphasis on functional preservation. Meanwhile, focal therapies such as cryoablation and irreversible electroporation (IRE) have emerged as promising treatment options for carefully selected patients.
Advances in ADC Therapy for Advanced Urothelial Carcinoma | Prof. Kaiwei Yang Reviews the Evolving First- and Later-Line Treatment Landscape

Advances in ADC Therapy for Advanced Urothelial Carcinoma | Prof. Kaiwei Yang Reviews the Evolving First- and Later-Line Treatment Landscape

The treatment landscape for advanced urothelial carcinoma (UC) has entered a new era. Antibody-drug conjugates (ADCs) targeting Nectin-4, HER2, and Trop-2 have rapidly transformed clinical practice, while ADCs combined with immune checkpoint inhibitors have become the new standard for first-line treatment. At the 2026 CSCO Annual Meeting, Prof. Kaiwei Yang from the Department of Urology, Peking University First Hospital presented a comprehensive overview of the current evidence supporting approved and investigational ADCs. Drawing on the latest 2026 CSCO Guidelines, he systematically reviewed first-line treatment strategies, sequencing after disease progression, breakthroughs in domestically developed ADCs, and the next generation of emerging targets, providing valuable insights into individualized treatment for advanced urothelial carcinoma.
BOC 2026 | Prof. Pei Dong: Kidney Cancer Enters the Era of Long-Term Survival, with New Advances in Adjuvant Therapy and Comprehensive Disease Management

BOC 2026 | Prof. Pei Dong: Kidney Cancer Enters the Era of Long-Term Survival, with New Advances in Adjuvant Therapy and Comprehensive Disease Management

In renal cell carcinoma (RCC), continued advances in targeted therapy and immunotherapy have ushered patients with advanced disease into an era of long-term survival and chronic disease management. However, important clinical challenges remain, including optimizing adjuvant treatment for high-risk patients after surgery, selecting effective therapies following immunotherapy resistance, and developing multidisciplinary models for comprehensive care throughout the disease course.
CUDA 2026 | Prof. Nianzeng Xing: Advancing Urology Through Collaboration and Innovation

CUDA 2026 | Prof. Nianzeng Xing: Advancing Urology Through Collaboration and Innovation

The 2026 Annual Meeting of the Chinese Urological Association (CUDA) was held in Zhengzhou from June 11–14, 2026. As one of China's most influential national academic meetings in urology, this year's conference adopted the theme "Collaboration and Innovation", bringing together leading domestic and international experts to discuss advances in minimally invasive surgery, robotic technology, precision medicine, and multidisciplinary cancer care, while promoting high-quality specialty development and the translation of scientific advances into clinical practice.
CUDA 2026 | Rethinking Tiered Healthcare and Multidisciplinary Care in Urology—An Interview with Prof. Zhisong He

CUDA 2026 | Rethinking Tiered Healthcare and Multidisciplinary Care in Urology—An Interview with Prof. Zhisong He

The 2026 Annual Meeting of the Chinese Urological Association (CUDA) was held in Zhengzhou under the theme "Collaboration and Innovation." The conference focused on key topics including precision diagnosis and treatment of urologic diseases, comprehensive cancer management, and multidisciplinary team (MDT) care, showcasing China's latest advances in technological innovation and the standardization of clinical practice.
CUDA 2026 | Prof. Xingyuan Xiao: Rethinking Comprehensive Urologic Cancer Management Through the Integration of Traditional Chinese and Western Medicine and MDT

CUDA 2026 | Prof. Xingyuan Xiao: Rethinking Comprehensive Urologic Cancer Management Through the Integration of Traditional Chinese and Western Medicine and MDT

The 2026 Annual Meeting of the Chinese Urological Doctor Association (CUDA 2026) was held in Zhengzhou, Henan, from June 11 to 14. Prof. Xingyuan Xiao of Zhongnan Hospital of Wuhan University has long been engaged in the clinical management and research of urologic diseases, with extensive experience in integrating traditional Chinese medicine (TCM) and Western medicine for urologic cancers and treatment-related complications.