
The 2026 International AIDS Conference (AIDS 2026) was successfully held in Rio de Janeiro, Brazil. The conference covered multi-dimensional topics including HIV prevention, diagnosis and treatment, and long-term disease management, bringing together scholars from the global infectious disease field for academic exchanges. Professor James McMahon from the Alfred Hospital and Monash University, Australia presented data from a 104-week Phase II clinical trial at the conference, focusing on evaluating the efficacy and safety of a half-yearly long-acting triple regimen combining lenacapavir, teropavimab and zinlirvimab. Long-acting administration represents a key developmental direction for current HIV therapy, drastically alleviating the daily pill-taking burden on patients and offering new insights for optimized long-term disease management. Infectious Disease Frontier conducted an exclusive interview with Professor McMahon to discuss the sustained viral suppression effects, tolerability profiles and target patient populations of this innovative long-acting triple regimen based on core primary clinical trial data, for reference by frontline clinical practitioners.