Antimicrobial resistance (AMR) continues to pose a serious threat to global health systems, particularly in high-burden countries like India. The challenges it presents to surgical treatment are complex and evolving, demanding both robust surveillance and strategic preventive interventions. In this interview, Dr. Camilla Rodrigues from Hinduja Hospital shares the current epidemiological landscape of AMR in India, discusses the risks it poses to surgical patients, and outlines successful approaches her center has implemented to mitigate these threats—particularly through systematic MRSA decolonization and strengthened infection control protocols.