Professor Haihong Wang: UNION TNT Study Highlights the Potential of Precision Combination Therapy for HER2-Expressing Locally Advanced Rectal Cancer

Professor Haihong Wang will present the UNION TNT study, which explores short-course radiotherapy combined with disitamab vedotin and immunochemotherapy for patients with HER2-expressing locally advanced rectal cancer. Preliminary findings demonstrate remarkable clinical benefit, with a pathological complete response (pCR) rate of 75% among patients who underwent surgery, while several additional patients achieved clinical complete response (cCR). These encouraging results underscore the significant potential of precision targeted combination therapy in the immunotherapy era to improve treatment efficacy while maximizing opportunities for organ preservation.

Professor Yi Yi Yu: Building a High-Quality IIT Research System at Zhongshan Hospital

This presentation provided an in-depth overview of Zhongshan Hospital's investigator-initiated trial (IIT) research system, highlighting its practical experience in infrastructure development, digital platforms, and talent cultivation. Through the implementation of the CREMS management platform, a dual electronic data capture (EDC) system, and the institutional innovation known as the "Zhongshan Ten Measures," the hospital has established a closed-loop quality management system covering the entire clinical research process. This model emphasizes standardized management spanning scientific review through to research translation, providing a robust foundation for medical innovation.
Pujiang Prostate Cancer Summit | Professor Jianming Guo: Breaking Through CRPC Resistance and Why Cytoreductive Surgery for Oligometastatic Disease Is Emerging as the Next Frontier

Pujiang Prostate Cancer Summit | Professor Jianming Guo: Breaking Through CRPC Resistance and Why Cytoreductive Surgery for Oligometastatic Disease Is Emerging as the Next Frontier

The 2026 Pujiang Prostate Cancer Summit was successfully held in Shanghai on June 26–27. Hosted by the Shanghai Anti-Cancer Association and organized by Fudan University Shanghai Cancer Center, the meeting brought together leading experts through keynote lectures, multidisciplinary (MDT) discussions, and live surgical demonstrations to highlight the latest advances in prostate cancer management. Among the meeting's major themes, personalized and precision treatment strategies attracted particular attention.
Pujiang Prostate Cancer Summit | Professor Dingwei Ye: Expanding Early Screening, Standardizing Care, and Advancing Clinical Research—Three Pillars to Narrow China’s Prostate Cancer Survival Gap

Pujiang Prostate Cancer Summit | Professor Dingwei Ye: Expanding Early Screening, Standardizing Care, and Advancing Clinical Research—Three Pillars to Narrow China’s Prostate Cancer Survival Gap

The 2026 Pujiang Prostate Cancer Summit was held in Shanghai on June 26–27 under the theme "Standardization, Precision, Chinese Innovation, and Global Collaboration." The meeting brought together leading experts in genitourinary oncology to showcase the latest advances in standardized prostate cancer management and innovative treatment strategies.
Clear Horizons, Comprehensive Urologic Care | Professor Xin Yao: ADT Remains the Cornerstone of Prostate Cancer Management, While LHRH Antagonists Deliver Both Clinical Efficacy and Quality of Life

Clear Horizons, Comprehensive Urologic Care | Professor Xin Yao: ADT Remains the Cornerstone of Prostate Cancer Management, While LHRH Antagonists Deliver Both Clinical Efficacy and Quality of Life

In this edition of Clear Horizons, Comprehensive Urologic Care, Professor Xin Yao from Tianjin Medical University Cancer Institute and Hospital discusses the mechanistic and clinical differences between LHRH agonists and antagonists, as well as practical strategies for managing ADT-related adverse events to maximize both treatment efficacy and patient quality of life.
APPLE 2026 | Prof. Stephen L. Chan: The Art and Science of Conversion Therapy in Cholangiocarcinoma 

APPLE 2026 | Prof. Stephen L. Chan: The Art and Science of Conversion Therapy in Cholangiocarcinoma 

Cholangiocarcinoma is characterized by its high malignancy, with the majority of patients presenting with unresectable disease at initial diagnosis. In recent years, conversion therapy—which utilizes systemic treatment to downsize tumors—has emerged as a pivotal, offering select patients a pathway to curative-intent resection. However, striking the right balance between therapeutic efficacy and overtreatment remains a significant clinical challenge. At APPLE 2026, Prof. Stephen L. Chan, from the Chinese University of Hong Kong (CUHK) Faculty of Medicine, offered an in-depth analysis of these issues during an exclusive interview with our journal. Prof. Chen advocates for earlier genomic testing for alterations such as FGFR2 and IDH1, and proposes a multidimensional assessment framework combining radiology with circulating biomarkers like ctDNA and MRD to precisely identify the optimal surgical window. Furthermore, he recommends a stratified postoperative strategy guided by pathological response (MPR/pCR) to maximize recurrence-free survival.
APPLE 2026 | Prof. Masatoshi Kudo: Reconstructing Systemic-Locoregional Therapeutic Strategies for Hepatocellular Carcinoma in the Immuno-Oncology Era 

APPLE 2026 | Prof. Masatoshi Kudo: Reconstructing Systemic-Locoregional Therapeutic Strategies for Hepatocellular Carcinoma in the Immuno-Oncology Era 

As hepatocellular carcinoma (HCC) treatment enters the wave of immuno-oncology (IO) combinations, the paradigm of combining systemic therapy with locoregional treatments (LRT) is undergoing a qualitative leap—evolving from incremental gains to a fundamental reconstruction. Held from July 3–5, 2026, the 16th Asia-Pacific Primary Liver Cancer Expert (APPLE) Meeting convened in Shanghai, bringing together leading experts from across the Asia-Pacific, Europe, and North America to discuss novel strategies for liver cancer prevention and management.
APPLE 2026 | Academician Jia Fan Invites You to APPLE 2026 in Shanghai: Witness China’s Growing Global Leadership in Liver Cancer and Explore AI-Driven Innovation 

APPLE 2026 | Academician Jia Fan Invites You to APPLE 2026 in Shanghai: Witness China’s Growing Global Leadership in Liver Cancer and Explore AI-Driven Innovation 

From July 3–5, 2026, the 16th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE 2026) will be held in Shanghai. Initiated by the Asia-Pacific Primary Liver Cancer Expert Association (APPLE), supported by the Shanghai Xinxin Medical Technology Development Foundation, and hosted by Zhongshan Hospital, Fudan University, the meeting will focus on the theme "Frontiers in the Diagnosis and Treatment of Primary Liver Cancer in the Era of Artificial Intelligence." Bringing together leading liver cancer experts from the Asia-Pacific region, Europe, and North America, APPLE 2026 will explore emerging strategies for liver cancer prevention and treatment. Following previous editions in 2012 and 2022, this marks the third time APPLE has been hosted in Shanghai, highlighting China's remarkable progress in healthcare, scientific research, and innovation over the past decade. Ahead of the meeting, Oncology Frontier spoke with Congress President Academician Jia Fan of Zhongshan Hospital, Fudan University, who reflected on APPLE's evolution, discussed the changing role of Chinese liver cancer specialists on the global stage, and shared his vision for how artificial intelligence (AI) will transform liver cancer care. Stay tuned for this landmark event.
ASCO 2026 | Prof. Li Mao: Ensartinib’s Global Strategy in the Intensifying ALK+ NSCLC Landscape

ASCO 2026 | Prof. Li Mao: Ensartinib’s Global Strategy in the Intensifying ALK+ NSCLC Landscape

On-site at the 2026 ASCO Annual Meeting, the targeted therapy landscape for ALK-positive non-small cell lung cancer (NSCLC) is witnessing intense competition, with multiple frontline updates from cutting-edge studies reshaping the global dynamics. As a pioneering Chinese homegrown innovative drug making its way onto the world stage, how can ensartinib—Betta Pharmaceuticals' proprietary ALK inhibitor—demonstrate its core value amidst formidable international rivals? MediaMedic had the privilege of an exclusive on-site interview with Professor Li Mao, President of R&D and Chief Medical Officer at Betta Pharmaceuticals, a seasoned leader deeply engaged in precision oncology, to deconstruct ensartinib's distinctive pathway to differentiation and global breakthrough. ADD HASHTAGS
ASCO 2026 | Prof. Kohei Shitara: T-DXd Establishes the New Standard for Second-Line HER2-Positive Advanced Gastric Cancer, with China’s Contributions Driving Global Progress

ASCO 2026 | Prof. Kohei Shitara: T-DXd Establishes the New Standard for Second-Line HER2-Positive Advanced Gastric Cancer, with China’s Contributions Driving Global Progress

The 2026 American Society of Clinical Oncology (ASCO) Annual Meeting, held in Chicago from May 29 to June 2, 2026, showcased several practice-changing advances in oncology. Among the highlights, Prof. Kohei Shitara from the National Cancer Center Hospital East, Japan, presented additional health-related quality of life (HRQoL) data from the landmark DESTINY-Gastric04 trial, further demonstrating the benefits of trastuzumab deruxtecan (T-DXd) in preserving patients' quality of life.