Posts by Mourabit Halima

In the golden autumn season, experts from across the Taiwan Strait gathered in Zhuhai. The 2026 Cross-Strait Hematology Academic Conference was held in Zhuhai, Guangdong, on August 21–22, bringing together hematology experts and scholars from both sides of the Taiwan Strait, as well as Hong Kong and Macao. The conference focused on cutting-edge developments and key areas of clinical practice, facilitating in-depth academic discussions and technical exchanges. A dedicated nursing session was held, featuring senior nursing experts from National Taiwan University Hospital (NTUH), who shared their clinical experience and provided a valuable platform for mutual learning, communication, and collaborative advancement in hematology nursing across the Taiwan Strait. During the conference, Oncology Frontier – Hematology Frontier invited Ms. Xia Yan from Peking University People's Hospital and Ms. Huiru Tsai from National Taiwan University Hospital to engage in an in-depth discussion on topics including the development of dedicated ICUs for hematology patients, infection prevention and control during CAR-T therapy followed by transplantation, and practical details of nursing care in laminar-flow rooms. Their discussion is summarized below for our readers.

The “Gaobo Medical Forum—6th Clinical Application Seminar and Training Course on Autologous Hematopoietic Stem Cell Transplantation,” hosted by the National Clinical Research Center for Hematologic Diseases of the Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences, and organized by Shanghai Zhaxin Hospital/Gaobo Medical Group and Shanghai Liquan Hospital, was held in Shanghai on August 29–30, 2026. During the meeting, Oncology Frontier – Hematology Frontier invited Dr. Shan Shao, Medical Team Leader at Gaobo Shanghai Zhaxin Hospital, to systematically discuss alternative treatment strategies for patients intolerant to calcineurin inhibitors (CNIs), drawing on the center's extensive clinical experience, and to share emerging explorations of anti-CD25 monoclonal antibodies as alternatives to CNI and short-course methotrexate (MTX) for GVHD prophylaxis.

TP53-abnormal B-ALL is widely recognized as one of the highest-risk and most refractory subtypes of B-ALL. Not only is it highly resistant to conventional chemotherapy, but it is also particularly prone to antigen escape and early relapse following immunotherapy, posing major challenges in clinical management. During the 2026 Cross-Strait Hematology Academic Conference, Oncology Frontier – Hematology Frontier invited Professor Xiaowen Tang from the First Affiliated Hospital of Soochow University to provide a systematic interpretation of the tumor biological characteristics and high-risk factors of TP53-abnormal B-ALL. Professor Tang also discussed strategies for optimizing CAR-T therapy through lymphodepletion regimen optimization and multi-target design, as well as the comprehensive management pathway involving bridging to allogeneic hematopoietic stem cell transplantation (allo-HSCT), and looked ahead to future breakthroughs in precision risk stratification, relapse prediction, and integrated treatment.TP53-abnormal B-ALL is widely recognized as one of the highest-risk and most refractory subtypes of B-ALL. Not only is it highly resistant to conventional chemotherapy, but it is also particularly prone to antigen escape and early relapse following immunotherapy, posing major challenges in clinical management. During the 2026 Cross-Strait Hematology Academic Conference, Oncology Frontier – Hematology Frontier invited Professor Xiaowen Tang from the First Affiliated Hospital of Soochow University to provide a systematic interpretation of the tumor biological characteristics and high-risk factors of TP53-abnormal B-ALL. Professor Tang also discussed strategies for optimizing CAR-T therapy through lymphodepletion regimen optimization and multi-target design, as well as the comprehensive management pathway involving bridging to allogeneic hematopoietic stem cell transplantation (allo-HSCT), and looked ahead to future breakthroughs in precision risk stratification, relapse prediction, and integrated treatment.

Extramedullary disease (EMD), an aggressive manifestation of multiple myeloma, presents longstanding challenges in clinical management, including substantial biological heterogeneity, difficulties in diagnosis and response assessment, resistance to conventional therapies, and a lack of high-level evidence from clinical trials. During the 2026 Cross-Strait Hematology Conference, Prof. Cai Zhen of the First Affiliated Hospital of Zhejiang University School of Medicine spoke with Oncology Frontier – Hematology Frontier about the key challenges of EMD, including target antigen escape, an immunosuppressive microenvironment, and difficulties in imaging-based response assessment. He also reviewed the latest advances and evolving treatment strategies involving bispecific antibodies, CAR-T-cell therapy, and novel antibody-drug conjugates (ADCs), providing authoritative and cutting-edge clinical insights into improving outcomes for patients with this high-risk disease subtype.

Cellular immunotherapies such as CAR-T therapy are rapidly evolving, progressing from single-target and dual-target approaches to armored CAR-T cells, in vivo CARs, and other next-generation technologies that continue to overcome the limitations of conventional therapies. The 2026 Cross-Strait Hematology Academic Conference was held in Zhuhai, Guangdong, on August 21–22. During the conference, Oncology Frontier – Hematology Frontier interviewed Professor Huang He from the First Affiliated Hospital of Zhejiang University School of Medicine for an in-depth discussion on advances in novel cellular immunotherapies and their clinical translation. Drawing on his team's original research, Professor Huang systematically discussed key strategies for enhancing CAR-T cytotoxicity, overcoming the bottlenecks of universal manufacturing, and reducing treatment costs, providing a clear roadmap for translating next-generation cellular therapies into clinical practice.