Combatting Carbapenem-Resistant Enterobacteriaceae Bloodstream Infections in Neutropenic Pediatric Hematology Patients: A Comprehensive Analysis

Combatting Carbapenem-Resistant Enterobacteriaceae Bloodstream Infections in Neutropenic Pediatric Hematology Patients: A Comprehensive Analysis

2024.02.29
In July 2023, a  study led by Professor XiaoFan Zhu from Chinese Academy of Medical Sciences Blood Disease Hospital (Institute of Hematology, Chinese Academy of Medical Sciences) was published in the international academic journal——Antimicrobial Resistance and Infection Control. The title of the study is "High risk of bloodstream infection of carbapenem-resistant enterobacteriaceae carriers in neutropenic children with hematological diseases". The analysis underscores the critical threat posed by carbapenem-resistant Enterobacteriaceae (CRE) bloodstream infections (BSIs) in neutropenic pediatric hematology patients.
Measurable Residual Disease in Leukemia: Improving Qualification through MRDworst case

Measurable Residual Disease in Leukemia: Improving Qualification through MRDworst case

2024.02.28
In November 2023, a  study led by Professor XiaoFan Zhu from Chinese Academy of Medical Sciences Blood Disease Hospital (Institute of Hematology, Chinese Academy of Medical Sciences) was published in the international academic journal——Leukemia（11.4）. The title of the study is "Have we been qualifying measurable residual disease correctly?". The comparative analysis between MRDworst case and MRDconventional methodologies reveals a clear advantage in favor of the former, particularly in its capacity to enhance the accuracy of relapse risk prediction in leukemia patients.
Advancing Prognostic Assessment in Pediatric Acute Myeloid Leukemia with KMT2A Rearrangement: Integrating Transcriptomic Profiling

Advancing Prognostic Assessment in Pediatric Acute Myeloid Leukemia with KMT2A Rearrangement: Integrating Transcriptomic Profiling

2024.02.28
In November 2023, a study led by Professor XiaoFan Zhu from Chinese Academy of Medical Sciences Blood Disease Hospital (Institute of Hematology, Chinese Academy of Medical Sciences) was published in the international academic journal ——Hemasphere. The title of the study is "Integration of Transcriptomic Features to Improve Prognosis Prediction of Pediatric Acute Myeloid Leukemia With KMT2A Rearrangement". The study represents a significant advancement in the prognostic assessment of pediatric acute myeloid leukemia (AML) with KMT2A rearrangement.
Establishment of a Prognostic Model and Tumor Clustering for Pediatric Acute Myeloid Leukemia Patients: Leveraging the Fanconi Anemia Signaling Pathway to Enhance Clinical Management

Establishment of a Prognostic Model and Tumor Clustering for Pediatric Acute Myeloid Leukemia Patients: Leveraging the Fanconi Anemia Signaling Pathway to Enhance Clinical Management

2024.02.28
In November 2023, a  study led by Professor XiaoFan Zhu from Chinese Academy of Medical Sciences Blood Disease Hospital (Institute of Hematology, Chinese Academy of Medical Sciences) was published in the international academic journal ——Open Medicine(Wars). The title of the study is "Establishing a novel Fanconi anemia signaling pathway-associated prognostic model and tumor clustering for pediatric acute myeloid leukemia patients". This study heralds the establishment of a novel prognostic model and tumor clustering approach tailored specifically for pediatric AML, anchored in the FA signaling pathway.
Long-Term Outcome of Rabbit Anti-Thymocyte Globulin and Cyclosporine Therapy for Pediatric Severe Aplastic Anemia

Long-Term Outcome of Rabbit Anti-Thymocyte Globulin and Cyclosporine Therapy for Pediatric Severe Aplastic Anemia

2024.02.28
In May 2023, a  study led by Professor XiaoFan Zhu from Chinese Academy of Medical Sciences Blood Disease Hospital (Institute of Hematology, Chinese Academy of Medical Sciences) was published in the international academic journal ——Blood Science. The title of the study is "An investigation of long-term outcome of rabbit anti-thymocyte globulin and cyclosporine therapy for pediatric severe aplastic anemia". This study holds significant implications for the clinical management of pediatric severe aplastic anemia.
Acinetobacter spp. Bloodstream Infection in Hematological Patients: A 10-Year Single-Center Study 

Acinetobacter spp. Bloodstream Infection in Hematological Patients: A 10-Year Single-Center Study 

2024.02.28
In November 2023, a  study led by Professor XiaoFan Zhu from Chinese Academy of Medical Sciences Blood Disease Hospital (Institute of Hematology, Chinese Academy of Medical Sciences) was published in the international academic journal ——BMC Infectious Diseases. The title of the study is "Acinetobacter spp. Bloodstream Infection in Hematological Patients: A 10-Year Single-Center Study". This comprehensive study sheds light on the significant burden of Acinetobacter spp. BSI in hematological patients, emphasizing the complexity of treating these infections in a population at high risk of adverse outcomes.
Unraveling the Complexity of Acute Myeloid Leukemia: Insights from Single-Cell Analysis

Unraveling the Complexity of Acute Myeloid Leukemia: Insights from Single-Cell Analysis

2024.02.28
In November 2023, a  study led by Professor XiaoFan Zhu from Chinese Academy of Medical Sciences Blood Disease Hospital (Institute of Hematology, Chinese Academy of Medical Sciences) was published in the international academic journal ——BMC Bioinformatics. The title of the study is "Detection of continuous hierarchical heterogeneity by single-cell surface antigen analysis in the prognosis evaluation of acute myeloid leukaemia". This study embarks on a pioneering endeavor to decode the continuous hierarchical heterogeneity embedded within AML using single-cell surface antigen analysis.