Frontiers in Immunology | Germline Genetic Susceptibility Genes May Enable More Precise Donor Selection for Hematopoietic Stem Cell Transplantation — Clinical Insights from a 558-Patient Transplant Cohort
As precision medicine continues to advance in hematologic malignancies, the clinical value of germline genetic factors is gradually extending beyond disease-risk assessment to influence treatment decision-making. For patients undergoing hematopoietic stem cell transplantation (HSCT), donor selection has traditionally focused on factors such as HLA matching, donor–recipient relationship, donor age, and overall health status. However, an increasingly important question is: Could the germline genetic backgrounds shared by or differing between donors and recipients also affect post-transplant disease control, infection risk, and long-term survival?









