EHA Reflections | Professor Fengkui Zhang: Oral Factor B Inhibitor Shows Superior Efficacy and May Redefine First-Line Treatment for PNH
Complement C5 inhibitors have transformed the management of paroxysmal nocturnal hemoglobinuria (PNH) and remain the current standard first-line therapy. However, despite effective control of intravascular hemolysis, many patients continue to experience persistent anemia, limited hemoglobin recovery, and clinically significant extravascular hemolysis, leaving substantial unmet medical needs.









