Angioimmunoblastic T-cell lymphoma (AITL), as a major subtype of peripheral T-cell lymphoma (PTCL), poses significant challenges for clinicians due to its complex pathological features, variable clinical presentation, and poor prognosis. In recent years, with advances in medical research, novel diagnostic techniques and treatment methods for nTFHL have emerged, leading to new breakthroughs in diagnosis and therapy. However, patient outcomes remain bleak, underscoring the urgent need for further basic and clinical research to guide clinical practice and improve prognosis. Recently, Dr. Jianyong Li from Jiangsu Province Hospital provided a detailed overview of the latest research progress in nodal T-follicular helper cell lymphoma (nTFHL). Hematology Frontier has compiled these insights for our readers.