Professor Edmund Chiong: Advances in PARP Inhibitor Combination Therapy and Precision Application
In recent years, with the continued advancement of precision medicine, PARP inhibitors have assumed an increasingly important role in prostate cancer treatment, particularly among patients harboring homologous recombination repair (HRR) gene alterations, in whom they have demonstrated clear clinical benefits. At the same time, a range of combination strategies involving PARP inhibitors and androgen receptor pathway inhibitors (ARPIs), immunotherapy, chemotherapy, and other treatment modalities have emerged, ushering advanced prostate cancer into an era of combination therapy. However, despite the rapid accumulation of clinical evidence, questions remain regarding the optimal treatment sequence, differences in benefit across specific HRR mutation subtypes, and strategies for managing resistance in the setting of combination therapy. Further evidence is needed to clarify these issues.









