ESMO Expert Commentary | Professor Yao Zhu: Success or Failure Does Not Define a Hero, Numerous Prostate Cancer Studies Aid in Optimizing Patient Survival

ESMO Expert Commentary | Professor Yao Zhu: Success or Failure Does Not Define a Hero, Numerous Prostate Cancer Studies Aid in Optimizing Patient Survival

Prostate cancer is the leading male urological tumor in China and has become one of the fastest-growing male malignancies in the past decade. The recent ESMO conference unveiled several advancements in prostate cancer research, extending the survival prospects for patients. Although there were some negative results, the research still holds positive significance. "Oncology Frontier" has specially invited Professor Yao Zhu from Fudan University's affiliated Cancer Hospital to provide an in-depth interpretation of these research developments.
Dr. Iskandar Azwa: Second and Third-Line Treatment Options for HIV/AIDS Patients

Dr. Iskandar Azwa: Second and Third-Line Treatment Options for HIV/AIDS Patients

Chairman of the Malaysian AIDS Council, Head of Infectious Diseases Department at the University of Malaya Medical Center. His research interests include pre-exposure prophylaxis (PrEP) implementation in key populations, HIV drug resistance, and evaluating new HIV treatment strategies. He is the principal investigator for several international collaborative HIV clinical trials, including TAHOD, START, and D2EFT studies.
APASL 2023 | Professor Li Jun: Latest Developments in ACLF Early Warning Models, Pioneering with Large-Scale Data from China

APASL 2023 | Professor Li Jun: Latest Developments in ACLF Early Warning Models, Pioneering with Large-Scale Data from China

Acute-on-Chronic Liver Failure (ACLF) is a complex syndrome characterized by acute deterioration of liver function on the background of chronic liver disease, accompanied by liver and/or extrahepatic organ failure. It poses a significant challenge in internal medicine due to its high short-term mortality rate of 50% to 90%. Early prediction of the risk of ACLF in patients and advancing the treatment window can effectively improve patient outcomes.
ILCA 2023 | Molecular typing based on fatty acid degradation metabolism helps in achieving precision treatment for liver cancer.

ILCA 2023 | Molecular typing based on fatty acid degradation metabolism helps in achieving precision treatment for liver cancer.

Primary liver cancer is currently the 4th most common malignant tumor and the 2nd leading cause of tumor-related death in China. 75%~85% of these cases are Hepatocellular carcinoma (HCC), posing a serious threat to the health and lives of Chinese citizens. In recent years, with the progress in traditional therapies like surgery, intervention, radiation, targeted therapy, and immunotherapy, there are now more options available for liver cancer patients. Recent clinical studies have shown that the combined treatment plan of atezolizumab and bevacizumab (referred to as “T+A”) can reduce the mortality risk of advanced liver cancer patients by 42% compared to the traditional targeted drug sorafenib, setting a new standard for the first-line treatment of advanced liver cancer. However, the overall survival rate of liver cancer patients remains unsatisfactory, with a 5-year survival rate of about 20%. Due to the heterogeneity of liver cancer, there is still a significant variance in the treatment response and prognosis of patients with the same clinical stage. How to select the most suitable individualized treatment method for different liver cancer patients, to maximize therapeutic effects, is a pressing issue in the clinic.