Dr. Peter Schmid：KEYNOTE-522 Study OS Results Update, Pembrolizumab Reshapes the Treatment Landscape for Early TNBC patients

Dr. Peter Schmid：KEYNOTE-522 Study OS Results Update, Pembrolizumab Reshapes the Treatment Landscape for Early TNBC patients

At the 2024 ESMO Congress, Dr. Peter Schmid from Barts Cancer Institute, Queen Mary University of London shared the overall survival data from the KEYNOTE-522 study with a follow-up of 75.1 months. The long-term follow-up results of the study showed that the combination of immunotherapy and chemotherapy significantly extended the event-free survival and overall survival of patients with triple-negative breast cancer, reducing the risk of recurrence and death. This breakthrough not only reaffirms the therapeutic position of immunotherapy in early triple-negative breast cancer but also points the way for further optimizing treatment plans in the future, bringing longer survival hopes for patients. Oncology Frontier specially invited Dr. Peter Schmid to share the relevant data.
China’s Prestigious Oncology Event: 2024 CSCO Annual Meeting Held in Xiamen

China’s Prestigious Oncology Event: 2024 CSCO Annual Meeting Held in Xiamen

Xiamen, China, September 25-29, 2024 — The 27th National Clinical Oncology Conference and the 2024 Academic Annual Meeting of the Chinese Society of Clinical Oncology (CSCO) commenced in Xiamen, embracing the theme "Patient-Centric, Shared Future." Jointly organized by the CSCO and the CSCO Foundation, the conference has brought together top experts and elites in oncology from both domestic and international fields to discuss the latest advancements, cutting-edge technologies, and future trends in cancer prevention and treatment.
Dr. Peiqi Zhao: New Drug Developments and Optimized Management – Upgrading the Comprehensive Treatment Strategy for Follicular Lymphoma

Dr. Peiqi Zhao: New Drug Developments and Optimized Management – Upgrading the Comprehensive Treatment Strategy for Follicular Lymphoma

From September 6 to 8, 2024, the 5th Tianjin International Lymphoma Conference was grandly held, attracting global experts to foster academic exchange and cooperation. During the conference, Hematology Frontier invited Dr. Peiqi Zhao from Tianjin Medical University Cancer Institute and Hospital to discuss the latest advances in follicular lymphoma treatment and the evolving concept of comprehensive disease management.
Dr. Lin Shen’s Team Confirms Promising Efficacy of Immunotherapy Combined with Chemotherapy as Neoadjuvant Treatment for Locally Advanced Esophageal

Dr. Lin Shen’s Team Confirms Promising Efficacy of Immunotherapy Combined with Chemotherapy as Neoadjuvant Treatment for Locally Advanced Esophageal

In April 2024, the 115th Annual Meeting of the American Association for Cancer Research (AACR) was held in San Diego, USA. As a global bellwether for new cancer drug development, the AACR meeting showcased numerous cutting-edge research findings in the field of oncology. One such study, conducted by Dr. Lin Shen's team from Peking Cancer Hospital, evaluated camrelizumab combined with chemotherapy as a neoadjuvant treatment for resectable locally advanced esophageal squamous cell carcinoma (LA-ESCC). This single-center, randomized, Phase II trial was selected for poster presentation at the conference, and Oncology Digest - Digestive Oncology News has summarized the key findings for readers.
Dr. Xiubao Ren: Exploring Tumor Immunotherapy from a “Reverse” Perspective – The Practice of Reverse Immune Editing Therapy

Dr. Xiubao Ren: Exploring Tumor Immunotherapy from a “Reverse” Perspective – The Practice of Reverse Immune Editing Therapy

The 5th Tianjin International Lymphoma Conference was successfully held from September 6 to 8, 2024. The conference featured 12 specialized sessions, including immunotherapy, basic translational research, and new drug development, providing a platform for international academic exchange and collaboration. During the event, Hematology Frontier invited Dr. Xiubao Ren from Tianjin Medical University Cancer Institute and Hospital to share insights on the progress of clinical trials in reverse immune editing therapy and its future application prospects in cancer treatment.
Dr. Shuquan Cheng: Common Factors Hindering Functional Cure in Chronic Hepatitis B

Dr. Shuquan Cheng: Common Factors Hindering Functional Cure in Chronic Hepatitis B

The reduction of hepatitis B surface antigen (HBsAg) levels in treated chronic hepatitis B (CHB) patients is closely linked to decreased risks of cirrhosis and even liver cancer. However, spontaneous HBsAg clearance occurs in less than 1% of patients per year. As CHB prevention and treatment guidelines continue to evolve both domestically and internationally, more patients are now pursuing "functional cures" through nucleos(t)ide analogs (NAs) combined with or followed by pegylated interferon (PEG-IFN) treatment. This approach offers the possibility of reducing or eliminating long-term or lifelong medication use. Clinically, even when patients use similar regimens aimed at achieving a functional cure, many continue to struggle along the difficult path to achieving HBsAg seroclearance, let alone reaching the ideal treatment endpoint of HBs seroconversion. Thus, understanding and recognizing the potential factors influencing functional cure is crucial for timely evaluation and intervention. This article summarizes the possible factors affecting CHB functional cure based on both domestic and international research to date.