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ELCC 2025 | Professor Rui Ma on the Final OS Results from the MARIPOSA Study
The 2025 European Lung Cancer Congress (ELCC) officially opened on March 26 in Paris, France. On the very first day, during the Proffered Paper Session 1, the highly anticipated final overall survival (OS) results from the MARIPOSA study (Abstract 4O) were presented.Oncology Frontier invited Professor Rui Ma of Liaoning Cancer Hospital to provide an in-depth…
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ELCC 2025 | Professor Gen Lin: Promising Results for Osimertinib Plus Dato-DXd in TKI-Resistant NSCLC from the ORCHARD Study
At the 2025 European Lung Cancer Congress (ELCC), new data from the ORCHARD study were presented, highlighting the potential of osimertinib in combination with Dato-DXd as a post-progression strategy following first-line osimertinib treatment in patients with EGFR-mutant non-small cell lung cancer (NSCLC). This marks the first public release of efficacy and safety findings for this…
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ELCC 2025 | Professor Lin Wu: Long-Term Benefit and Individualized Dose Reduction Strategies of Domestic Third-Generation EGFR-TKI in EGFR T790M-Mutated NSCLC
At the 2025 European Lung Cancer Congress (ELCC), the team led by Professor Lin Wu from the Hunan Cancer Hospital, Xiangya Hospital, Central South University, presented long-term follow-up data on ASK120067 (rezivertinib) in patients with locally advanced or metastatic EGFR T790M-mutant non-small cell lung cancer (NSCLC). Oncology Frontier invited Professor Wu to comment on the…
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ELCC 2025| Professor Wei Zhang on the Optimal Duration of Immunotherapy and Novel Strategies Beyond PD-(L)1 Inhibition
The recently concluded 2025 European Lung Cancer Congress (ELCC) spotlighted several key clinical topics and unveiled new research with strong translational potential. Oncology Frontier invited Professor Wei Zhang of Shanghai Chest Hospital, Shanghai Jiao Tong University for an in-depth interview, where she shared expert insights on the congress’s most impactful themes and dissected the scientific…
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Shaping the Future of AI in GI Care – Dr. Shahnaz Sultan’s Leadership in the 2025 AGA Guideline
Dr. Shahnaz Sultan led the multidisciplinary panel behind the AGA Living Clinical Practice Guideline on Computer-Aided Detection–Assisted Colonoscopy, published in April 2025 in Gastroenterology.This guideline addresses one of the most…
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Trastuzumab Deruxtecan Shows Intracranial Activity in HER2-Positive Breast Cancer with Active Brain Metastases
A patient-level pooled analysis combining the DEBBRAH and TUXEDO-1 trials along with the DFCI/Duke/MDACC cohort, published in ESMO Open (January 3, 2025), demonstrated clinically meaningful intracranial efficacy of trastuzumab deruxtecan…
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Blood Science Update| MicroRNAs: Discovery, Breakthrough, and Innovation
Historical Foundations and Discovery The origins of miRNA research trace back to the early 1990s, when Ambros and Ruvkun, both postdoctoral fellows in H. Robert Horvitz’s laboratory at MIT, investigated…
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Blood Science Update| Mitochondrial Genetic Variations in Leukemia: A Comprehensive Overview
Mitochondrial Genetics: A Distinct Layer of Complexity Mitochondria, as essential energy-generating organelles, possess a compact 16.5 kb circular genome encoding 37 genes critical for oxidative phosphorylation. Unlike nuclear DNA, mtDNA…