Informations

Study Design and Methods This single-center retrospective study analyzed 64 AML patients with KMT2A-PTD positivity at diagnosis who underwent HID HSCT between April 2016 and December 2020. Based on their…

Study Focus and Methods The authors conducted a comprehensive synthesis of existing literature, experimental data, and ongoing clinical trials to evaluate the roles of γδ T cell subsets in antitumor…

Despite over 100 million units of blood being donated annually, supply remains insufficient, particularly for patients with chronic conditions or in crisis settings. Alloimmunization and blood group incompatibilities further constrain transfusion efficacy. In response, researchers are exploring the use of induced pluripotent stem cells (iPSCs) to generate red blood cells (RBCs) in vitro as a…

Hemophilia A is a chronic bleeding disorder resulting from a deficiency in coagulation factor VIII (F8). Current treatment strategies rely on frequent F8 replacement therapy, which is limited by its short half-life, high cost, and the risk of inhibitor development. Gene therapy using adeno-associated virus serotype 8 (AAV8) has emerged as a promising modality, offering…

At the 2024 ASH Annual Meeting, Dr. Syed Osman Ahmed contributed to a study investigating the incidence of sinusoidal obstruction syndrome (SOS) in adults with relapsed/refractory B-cell acute lymphoblastic leukemia…