From Biological Mechanisms to Targeted Therapy: The Treatment of Immune Thrombocytopenia (ITP) Enters an Era of Precision丨EHA 2025

From Biological Mechanisms to Targeted Therapy: The Treatment of Immune Thrombocytopenia (ITP) Enters an Era of Precision丨EHA 2025

The 2025 European Hematology Association (EHA) Annual Meeting was grandly held both online and in-person, gathering top experts and scholars from the global hematology community. During the highly anticipated Presidential Symposium, Professor Nicola Cooper, an immune-hematologist from Imperial College London, delivered a keynote speech on "Immune Thrombocytopenia (ITP): From Biology to Targeted Therapy." She systematically reviewed the century-long evolution of ITP from its initial recognition to modern treatment, and by focusing on cutting-edge research, she outlined a clear roadmap for the future of personalized, precision therapy.
Overcoming Venetoclax Resistance in CLL: A Novel BCL2/BCL-xL Dual-Efficacy Degrader Reshapes the Therapeutic Landscape丨EHA 2025

Overcoming Venetoclax Resistance in CLL: A Novel BCL2/BCL-xL Dual-Efficacy Degrader Reshapes the Therapeutic Landscape丨EHA 2025

In the high summer of 2025, the highly anticipated European Hematology Association (EHA) Annual Meeting was convened, bringing together top global experts in hematologic oncology to discuss cutting-edge progress and future directions in the field. In the Chronic Lymphocytic Leukemia (CLL) session, Dr. Daisy Diaz, a postdoctoral fellow from MD Anderson Cancer Center in the United States, representing the team of her mentor, Professor Deepa Sampath, delivered an exceptional presentation titled "A Study on Transcriptional Reprogramming and Survival Co-dependencies Following Venetoclax Resistance in Chronic Lymphocytic Leukemia." This research systematically unveiled the complex resistance mechanisms in CLL after the failure of Venetoclax treatment and proposed an innovative solution based on Proteolysis-Targeting Chimera (PROTAC) technology, offering a highly promising new approach for clinically overcoming dual-drug resistance.