Hematology Frontier

Blinatumomab, a CD19/CD3 bispecific antibody, has demonstrated clear efficacy in relapsed/refractory and MRD-positive B-cell acute lymphoblastic leukemia (B-ALL). Its integration into frontline therapy for newly diagnosed patients is now being actively explored and may reshape treatment paradigms.

aploidentical hematopoietic stem cell transplantation (haplo-HSCT) has become an important curative approach for acute leukemia. However, post-transplant outcomes remain highly heterogeneous, and key determinants as well as optimal donor strategies are not yet fully defined.

The 52nd EBMT Annual Meeting was held in Madrid, Spain, from March 22 to 25, 2026. As one of the most influential global conferences in hematopoietic stem cell transplantation, the meeting showcased cutting-edge research and the latest clinical advances in the field.

The 52nd EBMT Annual Meeting was held in Madrid, Spain, from March 22 to 25, 2026. The conference focused on the latest advances in clinical hematology and hematopoietic stem cell transplantation, promoting continued progress in both clinical practice and translational research.

Relapsed acute myeloid leukemia (AML) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) carries an extremely poor prognosis, particularly in patients with high CD33 expression who are refractory to conventional salvage therapies, where treatment options remain very limited.

Relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains one of the major barriers to long-term survival in acute leukemia. With the rapid development of targeted therapies, hypomethylating agents, and immunotherapies such as CAR-T, salvage treatment options have expanded considerably. As a result, more patients are now able to achieve remission again and proceed to subsequent consolidation strategies.

In real-world clinical practice, a considerable proportion of patients with multiple myeloma (MM) are unable to tolerate autologous stem cell transplantation (ASCT) due to advanced age, comorbidities, or poor performance status, creating an urgent need for more effective therapeutic strategies. On February 27, 2026, a research paper entitled Phase II Study of BCMA Chimeric Antigen Receptor T-Cell Therapy in Patients With Newly Diagnosed Multiple Myeloma Ineligible for or Not Proceeding to Autologous Stem-Cell Transplantation (CAREMM-001) by a Chinese research team was published online in the Journal of Clinical Oncology (IF=43.4). This study provides the first prospective clinical evidence for the field, confirming that the upfront application of B-cell maturation antigen (BCMA) chimeric antigen receptor T-cell (CAR-T) therapy as first-line treatment for patients with newly diagnosed multiple myeloma (NDMM) who are ineligible for or not proceeding to transplantation—including those with high-risk disease—achieves an impressive 100% minimal residual disease (MRD) negativity rate and a 94.4% complete response rate (CRR) with a favorable safety profile. This novel therapeutic approach is expected to establish a new paradigm for MM treatment. This article summarizes the key findings of this landmark study for clinical reference.

Acute myeloid leukemia (AML) is a highly heterogeneous hematologic malignancy. Approximately 20–30% of AML patients harbor FLT3 internal tandem duplication (FLT3-ITD) mutations. FLT3-ITD is a major driver mutation in AML and typically arises as a late genetic event during leukemogenesis, often coexisting with mutations in NPM1, DNMT3A, WT1, and others. Although FLT3-ITD is generally associated with poor prognosis, substantial variability in clinical outcomes has been observed among FLT3-ITD–positive patients. Previous studies have largely focused on the molecular characteristics of FLT3-ITD itself, while the impact of its clonal origin on prognosis has been underexplored. Moreover, the key genetic evolutionary mechanisms driving resistance during progression from newly diagnosed disease to relapsed/refractory (R/R) AML remain incompletely understood.

From November 6 to 9, 2025, the China Conference on Holistic and Integrative Oncology (CCHIO 2025) was grandly convened in Kunming. As one of China’s largest and most influential oncology meetings, the conference gathered many leading national and international oncology experts to explore the latest advances and future directions in cancer prevention and treatment through the lens of integrative medicine. The event provided a high-level platform for strengthening China’s cancer diagnosis and treatment system.

mmunotherapy field, enhance communication on key scientific issues, share the latest clinical advances, and foster global collaboration and translational progress, the 2025 International Cell & Immunotherapy Congress (CTI 2025)—jointly organized by Zhejiang University, the International Academy for Clinical Hematology (IACH), Zhejiang Immunological Society and Zhejiang Anti-Cancer Association—was held on November 13–16, 2025 in Hangzhou, China, and co-hosted by the First Affiliated Hospital of Zhejiang University School of Medicine and the Liangzhu Laboratory.