EHA Reflections | Dr. Jing Pan: Novel Nanobody-Based Dual-Epitope CD5 CAR-T Uses Speed to Redefine T-ALL Immunotherapy
Treatment options remain extremely limited for patients with relapsed/refractory T-cell acute lymphoblastic leukemia (r/r T-ALL) who relapse after CD7 CAR-T therapy. Although previous studies of humanized CD5 CAR-T cells demonstrated encouraging antitumor activity, long-term follow-up revealed a significant safety challenge: a high incidence of severe and sometimes fatal infections.









