CDM Monthly Review (November 2023, Issue 75)

CDM Monthly Review (November 2023, Issue 75)

Hello experts and colleagues, in this 75th issue of the CDM Monthly Review for November 2023, we share six recent publications in the field of portal hypertension diagnosis and treatment (three on diagnosis and monitoring, and three on multidisciplinary treatment). This issue features guest experts: Dr. Bingtian Dong from the Department of Ultrasound at the First Affiliated Hospital of Anhui Medical University, Dr.Ningning Wang from the Department of Gastroenterology at the First Affiliated Hospital of China Medical University, Dr.Lei Zheng from the Department of General Surgery at the Ninth People's Hospital affiliated with Shanghai Jiao Tong University School of Medicine, and Dr. Sheng Wang from the Department of Gastroenterology at the Third Affiliated Hospital of Sun Yat-sen University.

Application of Ultrasound Elastography Scoring in Diagnosing Potential Porto-Sinusoidal Vascular Disease in Patients with Portal Vein Thrombosis

The "Hepatology Digest-Vascular Liver Disease Column" is an academic column jointly initiated by Dr. Xingshun Qi of the Department of Gastroenterology, Northern Theater Command General Hospital, at the invitation of the editorial department of " Hepatology Digest". This column regularly collects and organizes research progress in the field of vascular liver disease. Every two weeks (on Wednesday), an important piece of literature is selected for in-depth discussion. The aim is to help readers understand the rationale behind these advancements and to inspire clinical and scientific thinking, putting knowledge into practice.
Construction and Validation of a Hepatocellular Carcinoma Prognosis Model Based on Stress Granules

Construction and Validation of a Hepatocellular Carcinoma Prognosis Model Based on Stress Granules

In an effort to keep clinicians and researchers in the field of hepatology abreast of the latest academic knowledge and research trends, " Hepatology Digest " has collaborated with the "Journal of Clinical and Translational Hepatology" (JCTH) to introduce the "Journal Co-Read" section. Each week, this section selects and interprets highlights from a key publication, summarizing its main points in the hope of enhancing clinical diagnostic and treatment levels, inspiring research thinking, and improving writing skills.

Efficacy Analysis of “T+A” Therapy in Different Treatment Populations of HCC

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. Most patients are unable to undergo surgical resection at the time of diagnosis, making systemic therapy an important treatment approach for this group. The combination immunotherapy of Atezolizumab plus Bevacizumab (“T+A”) has become the new first-line standard treatment for unresectable HCC patients due to its significant improvement in overall survival (OS) compared to sorafenib. However, its effectiveness in different populations, including HCC patients with different etiologies, Child-Pugh B grade HCC, and intermediate-stage HCC beyond the up-to-seven criteria, remains unclear. The journal "Hepatology Digest" has reviewed recent studies on this topic for the benefit of readers.
Progress and considerations in the research of malnutrition in patients with cirrhosis

Progress and considerations in the research of malnutrition in patients with cirrhosis

Malnutrition, a subacute or chronic nutritional condition, arises from insufficient (or excessive) food intake and/or inflammation, leading to compromised body composition and reduced bodily functions, adversely affecting clinical outcomes and prognosis. Given the liver's central role in metabolizing glucose, proteins, and fats, patients with ongoing liver damage, especially cirrhosis, commonly suffer from malnutrition. Studies indicate that 40% to 90% of hospitalized patients with liver disease experience malnutrition. It is an independent predictor of mortality in cirrhosis patients and is closely linked to complications like ascites, hepatic encephalopathy, infections, and recent findings also suggest connections with reduced quality of life, sleep disorders, micronutrient deficiencies, and frailty.
Dr. Massimo Federico: 10-Year Follow-up Results of Early FDG-PET Adaptive Treatment for Limited-Stage HL

Dr. Massimo Federico: 10-Year Follow-up Results of Early FDG-PET Adaptive Treatment for Limited-Stage HL

At the International Malignant Lymphoma Conference (ICML 2023), Dr. Massimo Federico from University of Modena and Reggio Emilia, presented a captivating report on 10-Year Follow-up Analysis of the EORTC/LYSA/FIL H10 Randomized Intergroup Trial during the "Focus on Hodgkin Lymphoma" session. Oncology Frontier specially invited Dr. Federico for an in-depth interview on this topic.
The clinical insights gained from T-cell receptor sequencing in revealing the immune characteristics of liver cancer staging

The clinical insights gained from T-cell receptor sequencing in revealing the immune characteristics of liver cancer staging

T lymphocytes play a crucial role in human adaptive immunity by recognizing antigens major histocompatibility complex (MHC) molecules through specific T-cell receptors (TCRs) on their surface. 95% of T cells have TCRs composed of α and β peptide chains connected by disulfide bonds, forming an α/β heterodimer. Each chain consists of constant and variable domains. TCR diversity arises from the rearrangement of the variable (V), diversity (D), and joining (J) gene segments of the peptide chains, along with random nucleotide additions or deletions.
APASL 2023 | Prof. George Lau: Seeking the “Cure” for Liver Disease – A Hepatologist’s Thirty-Year Journey of Exploration

APASL 2023 | Prof. George Lau: Seeking the “Cure” for Liver Disease – A Hepatologist’s Thirty-Year Journey of Exploration

The 32nd annual meeting of the Asia-Pacific Association for the Study of the Liver (APASL) was held at the Taipei International Convention Center in Taiwan, China, from February 15 to 19, 2023. During the conference, the APASL Executive Committee awarded four prestigious honors, including the third APASL Highest Honor Award, the Okuda-Omata Outstanding Achievement Award, to Professor George Lau. Professor Lau, Chairman of the Universal Benevolence Medical Group in Hong Kong, China, and Co-Director of the Liver Disease and Transplant Center at the Fifth Medical Center of the PLA General Hospital in Beijing, in collaboration with the Universal Benevolence Medical Group, was recognized for his distinguished achievements. In his acceptance speech, Professor Lau delivered an inspiring message, encouraging his peers in hepatology to continue their relentless pursuit of curing liver diseases. We extend our heartfelt congratulations to Professor Lau and are pleased to share a translated version of his speech for our readers' encouragement and inspiration.
ASH 2023丨Professor Lin Tongyu: Decoding ASH Conference Insights on Lymphoma Treatment, Potential Revealed in r/r-PTCL with EZH1/2 Inhibitor HH2853

ASH 2023丨Professor Lin Tongyu: Decoding ASH Conference Insights on Lymphoma Treatment, Potential Revealed in r/r-PTCL with EZH1/2 Inhibitor HH2853

From December 9 to 12, the highly anticipated 65th American Society of Hematology (ASH) Annual Meeting took place in San Diego, USA. Focused on the annual pinnacle in the field of hematologic malignancies, the front-line reporting team of "Oncology Insights" delved into the forefront, witnessing the outstanding performance of "China's Good Voice" on the international stage. In the realm of aggressive lymphomas, advancements in targeted and cellular immunotherapy continue to dominate. To comprehensively grasp the lymphoma treatment developments at this ASH conference, "Oncology Insights" had the privilege of interviewing Professor Lin Tongyu from Sun Yat-sen University Cancer Hospital, who provided insightful analysis on the topic.