Launch of the K-COMPAsS Model: A New Era of Precise Prognostic Assessment for Oligometastatic Clear Cell Renal Cell Carcinoma

Launch of the K-COMPAsS Model: A New Era of Precise Prognostic Assessment for Oligometastatic Clear Cell Renal Cell Carcinoma

At a recent international academic conference, Professor Chad Tang from The University of Texas MD Anderson Cancer Center presented pioneering research on circulating Kidney Injury Molecule-1 (KIM-1) and circulating tumor DNA (ctDNA) as prognostic markers for oligometastatic clear cell renal cell carcinoma (ccRCC). During the session, he officially introduced the K-COMPAsS model.
Setback in First-Line Advanced Urothelial Carcinoma Exploration: Adding Anti-LAG-3/TIGIT to EV + Pembrolizumab Yields No Additional Benefit

Setback in First-Line Advanced Urothelial Carcinoma Exploration: Adding Anti-LAG-3/TIGIT to EV + Pembrolizumab Yields No Additional Benefit

At a recent international oncology academic conference, Professor Avivit Peer presented the latest findings from the KEYMAKER-U04 Substudy 04B. This study investigated the efficacy and safety of adding an anti-LAG-3 or anti-TIGIT antibody to the standard-of-care enfortumab vedotin (EV) plus pembrolizumab backbone as a first-line treatment for advanced urothelial carcinoma (UC). Our editorial team has summarized the core academic content for our readers.
The Era of Digital Pathology AI Has Arrived: Phase III CHHiP Trial Confirms MMAI Significantly Enhances Prostate Cancer Risk Stratification

The Era of Digital Pathology AI Has Arrived: Phase III CHHiP Trial Confirms MMAI Significantly Enhances Prostate Cancer Risk Stratification

With the continuous increase in the global incidence of prostate cancer and the variation in disease progression risk driven by tumor heterogeneity, accurate risk stratification is crucial for optimizing clinical treatment decisions. At a recent international oncology conference, Dr. Anna Clare Wilkins from The Institute of Cancer Research (ICR) and The Royal Marsden NHS Foundation Trust delivered a special presentation on the "External validation of a digital pathology-based multimodal artificial intelligence (MMAI) derived prognostic biomarker in the randomized phase III CHHiP trial" (Abstract 308). This study confirmed that MMAI can overcome the limitations of traditional clinicopathological models, significantly improving the predictive accuracy of survival endpoints in patients with localized prostate cancer. Our editorial team has compiled the core highlights of this presentation for our readers.
Precision Over Prolongation: IPD Meta-Analysis Challenges Routine Hormone Therapy in Recurrent Prostate Cancer

Precision Over Prolongation: IPD Meta-Analysis Challenges Routine Hormone Therapy in Recurrent Prostate Cancer

At the recent oncology conference, Dr. Amar Kishan, Radiation Oncologist at the University of California, Los Angeles (UCLA), presented Abstract 305, a highly anticipated individual patient data (IPD) meta-analysis addressing the optimal patient selection and duration for hormone therapy (HT) combined with post-operative radiotherapy (RT) in recurrent prostate cancer.
Rethinking “Very High-Risk”: Prof. Karim Fizazi on PEACE-2 Results and the Evolution of Prostate Cancer Risk Stratification

Rethinking “Very High-Risk”: Prof. Karim Fizazi on PEACE-2 Results and the Evolution of Prostate Cancer Risk Stratification

During a recent major international oncology congress, Professor Karim Fizazi from the University of Paris-Saclay (Gustave Roussy) presented the first results of the Phase III PEACE-2 trial. This study evaluated whether the addition of cabazitaxel and/or pelvic radiotherapy to the standard of care—androgen deprivation therapy (ADT) combined with prostate radiation—improves outcomes in patients with very high-risk localized prostate cancer.
Dr. Martin Gleave Deciphers GUNS Study: Triplet Therapy Significantly Increases MRD Rates in Genomically Aggressive Prostate Cancer

Dr. Martin Gleave Deciphers GUNS Study: Triplet Therapy Significantly Increases MRD Rates in Genomically Aggressive Prostate Cancer

At the 2025 American Society of Clinical Oncology Genitourinary Cancers Symposium (GU ASCO), Dr. Martin Gleave from the University of British Columbia presented the latest data from the GUNS study (Genomic Umbrella Neoadjuvant Study). The presentation focused on the pathological responses of high-risk prostate cancer (PCa) patients with aggressive genomic alterations treated with neoadjuvant androgen receptor pathway inhibitor (ARPI) triplet versus doublet regimens.
EBRT vs. Brachytherapy Boost in Localized Prostate Cancer: In-Depth Analysis of 15-Year OS and PCSM Data from the ASCENDE-RT Trial

EBRT vs. Brachytherapy Boost in Localized Prostate Cancer: In-Depth Analysis of 15-Year OS and PCSM Data from the ASCENDE-RT Trial

At a recent international oncology conference, Professor Scott Tyldesley from Vancouver, Canada, delivered an oral presentation on behalf of Professor Jim Morris, sharing the 15-year long-term survival analysis of the ASCENDE-RT trial (Abstract No. 306). This study compared the long-term overall survival (OS) and prostate cancer-specific mortality (PCSM) of an external beam radiotherapy (EBRT) boost versus a low-dose-rate (LDR) brachytherapy boost in patients with localized prostate cancer. Oncology Frontier (Mediamedic) has summarized the core academic highlights to share with our readers.
Professor Wang Sanbin: Advancing Integrative Rehabilitation and Translating Cutting-Edge Therapies in Lymphoma Care

Professor Wang Sanbin: Advancing Integrative Rehabilitation and Translating Cutting-Edge Therapies in Lymphoma Care

From November 6 to 9, 2025, the China Conference on Holistic and Integrative Oncology (CCHIO 2025) was grandly convened in Kunming. As one of China’s largest and most influential oncology meetings, the conference gathered many leading national and international oncology experts to explore the latest advances and future directions in cancer prevention and treatment through the lens of integrative medicine. The event provided a high-level platform for strengthening China’s cancer diagnosis and treatment system.
Professor YanminZhao: A New Management Framework for TP53 Mutations — From MRD Monitoring to Emerging Treatment Strategies | 2025 International Cell & Immunotherapy Congress

Professor YanminZhao: A New Management Framework for TP53 Mutations — From MRD Monitoring to Emerging Treatment Strategies | 2025 International Cell & Immunotherapy Congress

mmunotherapy field, enhance communication on key scientific issues, share the latest clinical advances, and foster global collaboration and translational progress, the 2025 International Cell & Immunotherapy Congress (CTI 2025)—jointly organized by Zhejiang University, the International Academy for Clinical Hematology (IACH), Zhejiang Immunological Society and Zhejiang Anti-Cancer Association—was held on November 13–16, 2025 in Hangzhou, China, and co-hosted by the First Affiliated Hospital of Zhejiang University School of Medicine and the Liangzhu Laboratory.