Voice of China Archives - Page 2 of 6

Dr. Zhaochong Zeng: Enhancing Efficiency and Reducing Burden – Latest Advances in Radiotherapy for Liver Cancer Treatment

By Mourabit Halima 2024.01.17

Stereotactic Body Radiotherapy (SBRT), as a novel radiotherapy technique, has achieved encouraging results in the treatment of liver cancer. It not only improves local tumor control but also reduces distant metastases caused by tumors. Additionally, it minimizes radiation therapy-related complications, enhancing the quality of life for patients after treatment. However, how to maximize the role of SBRT in comprehensive liver cancer treatment is a topic worthy of further exploration. At the 13th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE 2023), Dr. Zhaochong Zeng and his team from Zhongshan Hospital, Fudan University, China, presented two studies selected for oral and poster presentations, focusing on improving the effectiveness of SBRT and reducing radiation therapy-related adverse reactions, which attracted significant attention at the conference. In this article, Dr. Zeng shares insights into these two studies.

$Dr. Xiaofan Zhu’s Four Study of Rare and Refractory Pediatric Hematologic Diseases at 2023 EHA$

Dr. Xiaofan Zhu’s Four Study of Rare and Refractory Pediatric Hematologic Diseases at 2023 EHA

By Mourabit Halima 2024.01.16

The 28th European Hematology Association (EHA) Annual Congress was held in Frankfurt, Germany, from June 8 to 11, 2023. Dr Xiaofan Zhu and his team from the Children's Hematology Center at the Chinese Academy of Medical Sciences and Peking Union Medical College presented four abstracts at this EHA congress. These abstracts covered various aspects of research, including the prognostic factors for relapsed childhood acute lymphoblastic leukemia (ALL) treated with the CCLG-ALL2008 protocol in China, the use of Blinatumomab for 14 days in combination with chemotherapy to achieve minimal residual disease (MRD) conversion in pediatric B-ALL patients, the integration of transcriptomic features to improve prognosis prediction in pediatric acute myeloid leukemia (AML) with KMT2A rearrangements, and the effective treatment of pediatric non-sickle cell anemia (NSAA) with Hydroxyurea in combination with CSA. To gain a deeper understanding of these studies, Dr. Zhu has provided interpretations of the research findings, which are summarized below.

Dr. Peihua Lu: Targeting CD7 CAR-T Cells Holds Promise for Treating Central Nervous System T-Cell Lymphoblastic Lymphoma/Leukemia

By Mourabit Halima 2024.01.16

T-cell lymphoblastic lymphoma (T-LBL) is a highly malignant and rare lymphoma with aggressive behavior. It primarily affects adolescents, often presenting with mediastinal lymph node enlargement and commonly accompanied by pericardial and pleural effusions. In some cases, the disease can involve the central nervous system (CNS) with neurological manifestations. About 20% of patients progress to acute T-cell lymphoblastic leukemia (T-ALL) in advanced stages, which has a rapid progression and poor prognosis.

Incorporating Cytarabine in Pre-treatment for Haploidentical Stem Cell Transplantation in Extramedullary Acute Leukemia: Safety and Efficacy

By Mourabit Halima 2024.01.15

Allogeneic hematopoietic stem cell transplantation is among the most effective methods for treating malignant hematopoietic tumors. However, for extramedullary leukemia, even with high-intensity chemotherapy and transplantation, the recurrence rate remains high. To improve the prognosis, it's essential to optimize the pre-treatment plan and reduce recurrence.At this EBMT annual meeting,Dr. Min Xiong from Hebei Yanda Ludaopei Hospital reported a clinical study (Abstract No.: 1100). Results indicate that a pre-treatment regimen incorporating cytarabine for haploidentical hematopoietic stem cell transplantation to treat extramedullary leukemia is both safe and effective. We've invited Dr. Xiong for a interpretation of this research. This retrospective analysis was conducted on 36 patients with extramedullary leukemia who underwent haploidentical allogeneic hematopoietic stem cell transplantation at Beijing Ludaopei Hospital from August 2019 to March 2022. The pre-treatment regimen used BU/CY in 14 cases (38.9%) and TBI/CY in 22 cases (61.1%), combined with cytarabine (5 mg/kg, on days -3 and -2). The overall survival (OS), disease-free survival (DFS), and transplant-related mortality (TRM) of the patients were assessed.

Dr. Xingyu Cao: Post-transplant maintenance therapy with Chidamide in T-ALL patients is expected to reduce relapse and improve survival

By Mourabit Halima 2024.01.15

Acute T-cell lymphoblastic leukemia (T-ALL) is a highly heterogeneous malignant tumor of the hematopoietic system caused by the malignant transformation of T-cell precursors. It has significant differences from B-cell precursor acute lymphoblastic leukemia (BCP-ALL) in clinical features, cellular genetics, molecular biology, and abnormal signal transduction pathways. T-ALL accounts for 10%-15% in children and 20%-25% in adults. Adult T-ALL has a poor prognosis due to primary chemotherapy resistance and early recurrence, with a 5-year event-free survival rate of only 20%-50%. The main challenge for T-ALL patients after transplantation is recurrence. From April 23-26, 2023, the EBMT Annual Meeting was grandly held in Paris, France. At the meeting, Dr. Cao Xingyu from Hebei Yanda Ludao Pei Hospital reported a clinical study (abstract number: 351), which suggested that the use of Chidamide for maintenance treatment might improve the survival of T-ALL patients after allogeneic hematopoietic stem cell transplantation (Allo-HSCT).

Dr. Hui Wang: A Simple and Rapid Multi-Parameter Flow Cytometry Approach for the Diagnosis and Screening of Malignant Tumors and Related Diseases

By Peter W. PENG 2024.01.15

From June 8 to 12, 2023, the 28th European Hematology Association (EHA) Congress will be held in Frankfurt, Germany, bringing together experts and scholars from around the world to present exciting advances in research. In the field of hematology testing, multi-parameter flow cytometry (MFC) is an important clinical diagnostic method, and the development of fast, simple, and efficient protocols is essential for this technology. A real-world study (P588) conducted by Dr. Hui Wang's team from Hebei Yanda Ludaopei Hospital and Beijing Ludaopei Hospital has been selected for presentation at EHA. The study aims to introduce the research achievements of Ludaopei Hospital over the years: a rapid, simple, and efficient MFC test for screening and diagnosing malignant tumors and related diseases. To gain a deeper understanding of this research, "Oncology Insight" invited Professor Wang Hui to provide a detailed analysis, which is summarized below.

Dr. Huilai Zhang’s Team: Key Research in the Field of Hodgkin Lymphoma

By Lisa Cui 2024.01.15

The 28th European Hematology Conference/Annual Meeting (28th EHA Congress) was successfully held in Frankfurt, Germany from June 8-11, 2023. The conference was organized by the European Hematology Association (EHA). As one of the largest international conferences in the field of hematology worldwide, the EHA annual meeting gathered top hematology experts from around the globe, covering all aspects of hematology research. The conference featured oral presentations, poster presentations, and several other sessions. This edition of Oncology Frontier focuses on key clinical studies on Hodgkin lymphoma presented in the oral report session, providing a quick overview of the latest research advancements in this area.

Dr. Liu Hongxing and Wang Tong: Decoding Structural Aberrations of the PAX5 Gene in B-ALL and its Correlation with Diagnostic Classification and Treat

By Mourabit Halima 2024.01.15

Dr. Tong Wang Researcher in Clinical Medicine Director of the Cellular and Molecular Cytogenetics Laboratory at Ludaopei Medical Group Corresponding Author Dr. Hongxing Liu Executive Dean of Beijing Ludaopei Hematology…

Youth Forum of APACC 2023 | (5R)-5-hydroxytriptolide Holds Promise for HIV immunological Non-responders Receiving ART

By Mourabit Halima 2024.01.14

Hello everyone, I'm Xiaosheng Liu , a graduate student from Professor Taisheng Li's team of Peking Union Medical College Hospital, China. My primary research focus is on the mechanisms underlying immunological non-response in HIV/AIDS patients after long-term antiviral therapy and the development of therapeutic drugs for this condition. I'm delighted to participate in this year's APACC conference (2023) and present two poster studies conducted by our team at the conference. APACC is the most cutting-edge and top academic conference in the Asia-Pacific region for HIV/AIDS, and I hope to broaden my knowledge in various aspects through this conference.

IAS 2023 | Thymosin α1 Therapy for HIV Immunological Non-responders: A Single-arm Clinical Study

By Mourabit Halima 2024.01.14

As HIV treatment enters the post-ART era, drug side effects and complications have become significant factors affecting the quality of life for patients. Approximately 20% of patients, after 1-2 years of treatment, have viral loads below the detectable limit, but their CD4 cell count remains below normal levels, leading to poorer clinical outcomes. From 2021 to 2022, the Shanghai Public Health Clinical Center conducted a clinical study on the use of thymosin α1 for the treatment of HIV immunological non-responders. The study results were presented as an e-poster at the IAS 2023 conference (Abstract No. 4511). A total of 20 participants were enrolled in the study, undergoing treatment and follow-up for a duration of six months (Registration No. NCT04963712).