Professor John Mascarenhas Details Breakthrough Safety and Efficacy Data of INCA33989 in Patients with ET丨EHA 2025

Professor John Mascarenhas Details Breakthrough Safety and Efficacy Data of INCA33989 in Patients with ET丨EHA 2025

The 2025 European Hematology Association (EHA) Annual Meeting was recently held, bringing together top global experts in the field of hematologic malignancies to discuss the latest research findings and future directions. In the highly anticipated "Late-Breaking Abstract" session, Professor John Mascarenhas from the Icahn School of Medicine at Mount Sinai presented clinical study data on INCA33989, a novel, first-in-class monoclonal antibody specific to mutant calreticulin (CALR). The study results showed that INCA33989 demonstrated excellent safety and revolutionary therapeutic potential in previously treated patients with Essential Thrombocythemia (ET), with the potential to change the current treatment landscape
From Biological Mechanisms to Targeted Therapy: The Treatment of Immune Thrombocytopenia (ITP) Enters an Era of Precision丨EHA 2025

From Biological Mechanisms to Targeted Therapy: The Treatment of Immune Thrombocytopenia (ITP) Enters an Era of Precision丨EHA 2025

The 2025 European Hematology Association (EHA) Annual Meeting was grandly held both online and in-person, gathering top experts and scholars from the global hematology community. During the highly anticipated Presidential Symposium, Professor Nicola Cooper, an immune-hematologist from Imperial College London, delivered a keynote speech on "Immune Thrombocytopenia (ITP): From Biology to Targeted Therapy." She systematically reviewed the century-long evolution of ITP from its initial recognition to modern treatment, and by focusing on cutting-edge research, she outlined a clear roadmap for the future of personalized, precision therapy.