ASCO 2024丨Professor Meisel Discusses I-SPY2.2 Study on TROP-2 ADC Neoadjuvant Therapy

ASCO 2024丨Professor Meisel Discusses I-SPY2.2 Study on TROP-2 ADC Neoadjuvant Therapy

With advancements in medical research and technology, new therapies for complex diseases like breast cancer are continually emerging. Dato-DXd, a novel antibody-drug conjugate (ADC), shows potential in the treatment of breast cancer. The I-SPY2.2 trial, presented at ASCO 2024, utilizes an innovative trial design to demonstrate the efficacy of Dato-DXd as a monotherapy in HR-HER2-negative breast cancer, particularly in TNBC patients and those with positive immune markers. Oncology Frontier interviewed Professor Jane Lowe Meisel from Emory University's Winship Cancer Institute to delve into the innovative I-SPY 2.2 trial and its implications for personalized neoadjuvant therapy in high-risk breast cancer patients.
ASCO China Voice | Professor Min Yan: Utidelone Combined with Bevacizumab is Safe and Effective for Treating Brain Metastases in HER2-Negative Breast

ASCO China Voice | Professor Min Yan: Utidelone Combined with Bevacizumab is Safe and Effective for Treating Brain Metastases in HER2-Negative Breast

Brain metastasis from breast cancer has a high incidence, second only to lung cancer . Previous studies have shown that patients with brain metastases have poorer survival compared to those without brain metastases, with HER2-negative breast cancer brain metastasis patients having an even worse prognosis . Due to the blood-brain barrier (BBB), many drug treatments have limited intracranial objective response rates (ORR). Utidelone, a novel microtubule inhibitor developed in China, has shown potential for treating brain metastases due to its unique physicochemical properties that allow it to penetrate the BBB. At the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting, a multicenter phase II study led by Professor Min Yan from Henan Cancer Hospital was selected for presentation. This study explored the efficacy and safety of utidelone combined with bevacizumab in treating HER2-negative breast cancer brain metastases. "Oncology Frontier" invited Professor Min Yan to discuss the progress in treating breast cancer brain metastases, the study design and findings, and future perspectives.
ASCO Researchers Speak丨Professor Jin Li: Utidelone Becomes a New First-Line Combination Therapy Option for Advanced Gastric Cancer

ASCO Researchers Speak丨Professor Jin Li: Utidelone Becomes a New First-Line Combination Therapy Option for Advanced Gastric Cancer

At the 2024 American Society of Clinical Oncology (ASCO) annual meeting, a multi-center study led by Professor Jin Li from Shanghai GaoBo Oncology Hospital, China Pharmaceutical University, reported that utidelone demonstrated significant anti-tumor activity in various pre-treated advanced solid tumors, particularly in first-line treatment of advanced gastric cancer. Oncology Frontier invited Professor Jin Li to further interpret the study
EASL China Voice丨Professor Jian Gao Fan: Selective THR-β Agonist ASC41 Significantly Reduces Liver Fat and ALT Levels in MASH Patients After 12 Weeks

EASL China Voice丨Professor Jian Gao Fan: Selective THR-β Agonist ASC41 Significantly Reduces Liver Fat and ALT Levels in MASH Patients After 12 Weeks

From June 5 to 8, 2024, the European Association for the Study of the Liver (EASL) Annual Meeting was held in Milan, Italy. This major event brought together over 7,000 professionals, including clinicians, researchers, healthcare workers, patient representatives, and industry experts. During the conference, Professor Jian Gao Fan from the Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine presented a poster titled “ASC41, a selective THR-β agonist significantly reduces liver fat and ALT in biopsy-confirmed MASH patients after 12-week treatment: an interim analysis of a 52-week serial liver biopsy study,” which attracted considerable attention. Professor Fan shared with us the main findings and clinical significance of this research.
EASL Featured New Voices丨Functional Cure of Chronic Hepatitis B: A Promising Journey

EASL Featured New Voices丨Functional Cure of Chronic Hepatitis B: A Promising Journey

Chronic hepatitis B (CHB) remains a significant global health issue. At this year's European Association for the Study of the Liver (EASL) Annual Meeting, the functional cure of CHB emerged as a focal point of research. "Hepatology Digest" had the privilege of speaking with Mr. Graham Griffiths, Chief Brand Officer at Barinthus Biotherapeutics, to gain insights into the conference highlights and the latest advancements in CHB treatment. Mr. Griffiths not only shared his key takeaways from the event but also detailed the progress made in the pursuit of a functional cure for CHB. He emphasized that combining various therapeutic strategies holds promise for more effective treatments and expressed optimism about the collaborative spirit and innovative potential showcased at the conference.
EASL Voice of China丨Professor Yu Chen: Promising Prospects for HYX1 Liver Stem Cells in Treating Acute Liver Failure by Inhibiting Ferroptosis through Exosomes

EASL Voice of China丨Professor Yu Chen: Promising Prospects for HYX1 Liver Stem Cells in Treating Acute Liver Failure by Inhibiting Ferroptosis through Exosomes

Acute liver failure (ALF) is a severe liver injury caused by factors such as drugs, viruses, and ischemia-reperfusion injury, leading to massive hepatocyte apoptosis, necrosis, and potentially irreversible liver damage. The condition progresses rapidly, with high short-term mortality rates and poor prognosis, while medical treatment options are limited. Although liver transplantation is an effective strategy for treating ALF, its high cost, scarcity of donor livers, and lifelong requirement for immunosuppressants limit its clinical application. Therefore, new treatment methods for ALF are urgently needed. On June 7, 2024, at the European Association for the Study of the Liver (EASL) annual meeting in Milan, a study by Professor Yu Chen's team from Beijing YouAn Hospital, Capital Medical University, was presented as a poster (Abstract No. FRI-347). This study revealed the mechanism by which liver-derived stem cells (HYX1) can be used to treat ALF, providing new insights for the future clinical treatment of ALF.
EASL Voice of China丨Professor Jian Sun: Correlation Between Serum HBV RNA and Hepatocellular Carcinoma Risk in Chronic Hepatitis B Patients

EASL Voice of China丨Professor Jian Sun: Correlation Between Serum HBV RNA and Hepatocellular Carcinoma Risk in Chronic Hepatitis B Patients

Chronic hepatitis B (CHB) is a global public health issue, with hepatocellular carcinoma (HCC) being one of its most severe complications. Traditional viral markers have limited efficacy in predicting HCC risk, highlighting the need for new viral predictive indicators. On June 5, 2024, at the European Association for the Study of the Liver (EASL) annual meeting in Milan, Italy, Professor Jian Sun's team from Nanfang Hospital, Southern Medical University, presented a compelling poster on the predictive role of serum HBV RNA reduction in HCC risk among CHB patients undergoing nucleos(t)ide analog (NA) therapy (Abstract No. LBP-037).
EASL Express丨Latest Advances in Bulevirtide Treatment for Chronic Hepatitis D

EASL Express丨Latest Advances in Bulevirtide Treatment for Chronic Hepatitis D

Hepatitis D virus (HDV) is a defective virus that requires the hepatitis B surface antigen (HBsAg) to replicate. Co-infection with HBV and HDV is considered the most severe form of chronic viral hepatitis, accelerating liver-related mortality and the development of hepatocellular carcinoma (HCC). At the 2024 European Association for the Study of the Liver (EASL) annual meeting held in Milan, Italy from June 5-8, the latest research on the treatment of chronic hepatitis D (CHD) with Bulevirtide (BLV) drew significant attention. These studies not only provide new strategies and evidence-based medicine for CHD treatment but also lay the foundation for future research. This article compiles and organizes three key studies presented at the conference for our readers.
EASL Exclusive Interview丨Professor Jun Li: Comprehensive Research on Acute-on-Chronic Liver Failure from Pathogenesis to Clinical Treatment

EASL Exclusive Interview丨Professor Jun Li: Comprehensive Research on Acute-on-Chronic Liver Failure from Pathogenesis to Clinical Treatment

Acute-on-chronic liver failure (ACLF) is a complex syndrome characterized by acute liver function deterioration based on chronic liver disease, accompanied by high mortality rates of liver and extra-hepatic organ failure. The short-term mortality rate of comprehensive internal medicine treatment ranges from 50% to 90%. Due to its high mortality and complex pathogenesis, research and treatment strategies for ACLF are particularly crucial. From June 5-8, 2024, the European Association for the Study of the Liver (EASL) Annual Meeting was held in Milan, Italy, where Professor Jun Li 's team from the First Affiliated Hospital of Zhejiang University School of Medicine presented five research findings related to ACLF. Hepatology Digest invited Professor Jun Li to introduce the highlights and significance of these studies, share his conference insights, and discuss the future development of the ACLF field. The following is the interview transcript.
EASL China Voice丨Professor Shuangsuo Dang’s Team Showcases Three Achievements in Milan

EASL China Voice丨Professor Shuangsuo Dang’s Team Showcases Three Achievements in Milan

From June 5-8, 2024, the European Association for the Study of the Liver (EASL) Annual Meeting was successfully held in Milan, Italy. During this event, the team led by Professor Shuangsuo Dang from the Department of Infectious Diseases at the Second Affiliated Hospital of Xi’an Jiaotong University presented three significant clinical and basic research findings: real-world antiviral treatment for chronic hepatitis B (CHB), mechanisms and treatment of metabolic-associated fatty liver disease (MAFLD), and risk factors and mechanisms of hepatocellular carcinoma (HCC). This report covers these studies for our readers.