EHA 2025 Reflections | Prof. Jun Ma: China’s Hematology Shines in Europe—Youth Innovation and Homegrown Therapeutics Take Center Stage

EHA 2025 Reflections | Prof. Jun Ma: China’s Hematology Shines in Europe—Youth Innovation and Homegrown Therapeutics Take Center Stage

On June 12, local time, the 30th Annual Congress of the European Hematology Association (EHA 2025) opened in Milan, Italy. As one of the world’s premier hematology events, the congress focused on the latest advances across all hematologic subspecialties, showcasing evidence-based approaches in diagnosis and treatment, cutting-edge data from clinical and translational research, and innovations in diagnostics, technology, and risk stratification strategies. On site, Oncology Frontier – Hematology Frontier spoke with Professor Jun Ma of the Harbin Institute of Hematology & Oncology, who offered an overview of this year’s meeting and highlighted the outstanding performance of Chinese research teams.
EHA Expert Interview | Prof. Jian Hou Uncovers a New Mechanism of Drug Resistance in Multiple Myeloma Involving eccANKRD28

EHA Expert Interview | Prof. Jian Hou Uncovers a New Mechanism of Drug Resistance in Multiple Myeloma Involving eccANKRD28

The 30th Congress of the European Hematology Association (EHA 2025) was held from June 12 to 15 in Milan, Italy. As one of the world’s leading hematology meetings, this year’s event spotlighted the latest advances across hematologic subspecialties, featuring cutting-edge approaches in diagnosis and treatment, along with new findings in both clinical and translational research. Among the studies presented, a research project led by Professor Jian Hou from Renji Hospital, Shanghai Jiao Tong University School of Medicine, was selected for an oral presentation (Abstract S188). This study sheds light on the critical role of non-coding enhancer-type extrachromosomal circular DNA (eccDNA), specifically eccANKRD28, in the development of drug resistance in multiple myeloma (MM). Oncology Frontier – Hematology Frontier spoke with Prof. Hou onsite for an in-depth discussion of this work.
ASCO 2025 | Dr. Hongbing Liu: Two-Cycle Chemotherapy Plus Immunotherapy Offers New Hope for Elderly Patients with Advanced Lung Cancer

ASCO 2025 | Dr. Hongbing Liu: Two-Cycle Chemotherapy Plus Immunotherapy Offers New Hope for Elderly Patients with Advanced Lung Cancer

The 2025 American Society of Clinical Oncology (ASCO) Annual Meeting, one of the world’s most influential oncology conferences, was held in Chicago from May 30 to June 3. This year, a study led by Dr. Hongbing Liu from the Second Affiliated Hospital of Nanjing Medical University, in collaboration with the Jinling Clinical Medical College team, was selected for poster presentation (Abstract #8548). The research, titled "Camrelizumab Combined with Two-Cycle Chemotherapy as First-Line Therapy for Advanced Non-Small Cell Lung Cancer (NSCLC): A Dual-Arm, Single-Center, Phase II Study", addresses a critical clinical question: Can the duration of chemotherapy be safely reduced? The study offers important insights for personalized treatment strategies in elderly NSCLC patients. Below is an in-depth discussion with Dr. Liu on the key findings.
ASCO 2025 | Dr. Li Zhang’s OptiTROP-Lung03 Study Showcased in Oral Presentation: Sacituzumab Tirumotecan Emerges as a Breakthrough in Overcoming EGFR-Mutant NSCLC Resistance

ASCO 2025 | Dr. Li Zhang’s OptiTROP-Lung03 Study Showcased in Oral Presentation: Sacituzumab Tirumotecan Emerges as a Breakthrough in Overcoming EGFR-Mutant NSCLC Resistance

Sacituzumab tirumotecan, a novel TROP2-targeting antibody-drug conjugate (ADC) developed in China, has demonstrated promising therapeutic potential across multiple tumor types, including lung and breast cancer. At the 2025 ASCO Annual Meeting, a pivotal Phase II trial—OptiTROP-Lung03, led by Dr. Li Zhang of the Sun Yat-sen University Cancer Center—was selected for an oral presentation, marking a significant step for domestically developed TROP2-ADC therapy in tackling resistance in EGFR-mutant non-small cell lung cancer (NSCLC). With this presentation, Dr. Zhang brings Chinese innovation to the global oncology stage.
ASCO 2025 | Dr. Yan Huang’s Team Reports Phase I Results of BL-B01D1, Paving a New Path in Precision Treatment for SCLC

ASCO 2025 | Dr. Yan Huang’s Team Reports Phase I Results of BL-B01D1, Paving a New Path in Precision Treatment for SCLC

Small cell lung cancer (SCLC), often known as the “king of lung cancer,” has long relied on the EP regimen (cisplatin plus etoposide) as the foundation of first-line therapy for nearly three decades. Although recent years have seen the introduction of immunotherapy combined with chemotherapy, which has brought incremental survival benefits, long-term outcomes for patients remain limited. At the 2025 ASCO Annual Meeting, Dr. Yan Huang from Sun Yat-sen University Cancer Center presented the results of a Phase I study (Abstract #3002) on BL-B01D1, a bispecific antibody-drug conjugate (ADC) targeting EGFR and HER3, in patients with SCLC who had failed standard treatments. The study showed that in patients who progressed after first-line chemo-immunotherapy, BL-B01D1 achieved a median overall survival (OS) of 15.1 months and a confirmed objective response rate (ORR) of 75%—breakthrough data that may offer a potential new treatment option for this hard-to-treat disease. Oncology Frontier invited Dr. Huang to provide an in-depth interpretation of the study’s clinical significance and application prospects.
ASCO Live Update | Professor Niels van de Donk: Four Key Advantages of the Trispecific Antibody JNJ-5322 in R/R MM

ASCO Live Update | Professor Niels van de Donk: Four Key Advantages of the Trispecific Antibody JNJ-5322 in R/R MM

At the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting, Professor Niels van de Donk from VU University Medical Center, Amsterdam, presented the preliminary results of a first-in-human phase I study of a novel trispecific antibody (TsAb) for relapsed/refractory multiple myeloma (R/R MM) in an oral presentation (Abstract #S100). Oncology Frontier – Hematology Frontier invited Prof. van de Donk for an in-depth discussion on the study's findings and clinical implications. Highlights of the conversation are summarized below.