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Exploring a New Neoadjuvant Strategy with Toripalimab Combined with Chemotherapy to Further Improve Survival Benefits for MIBC Patients
For patients with muscle-invasive bladder cancer (MIBC), when the tumor is large, deeply invasive, or has local lymph node metastasis, the radicality of whole bladder surgery can be affected. Neoadjuvant therapy can enhance the rate of radical resection by downstaging the tumor, and it has become a current research hotspot. At this year’s ASCO Annual…
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ASCO Expert Interview丨Professor Qingqing Cai: CHESS Results Unveiled, Exploring “Chemo-Less” Treatment for Mantle Cell Lymphoma
The Phase II multicenter clinical trial (CHESS chemo-less, NCT04624958) aims to explore the efficacy and safety of zanubrutinib combined with rituximab followed by a short course of cytarabine-based chemotherapy, then maintained with zanubrutinib in newly diagnosed mantle cell lymphoma (MCL) patients. The 2024 American Society of Clinical Oncology (ASCO) Annual Meeting was grandly held in…
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Professor Kun Wang: The NeoMDSS Model Accurately Predicts pCR Rates after Neoadjuvant Therapy for Breast Cancer, Enhancing Personalized Treatment
Breast cancer is a malignant tumor that seriously threatens women’s health. Neoadjuvant therapy is a crucial means to provide more surgical opportunities and pave the way for a cure. However, the pathological complete response (pCR) varies significantly with different molecular subtypes and treatment regimens, making it challenging to predict treatment efficacy early in neoadjuvant therapy…
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ASCO Voice of China丨Professor Ying Fan: Breaking the mTNBC 2L+ Treatment Ceiling, China’s First TROP2 ADC, LuKangsa-Tropozumab, Leads to Longer PFS Benefits
The 60th American Society of Clinical Oncology (ASCO) Annual Meeting was held from May 31 to June 4, 2024, in Chicago, USA. During the meeting, Professor Binghe Xu from the Chinese Academy of Medical Sciences Cancer Hospital presented groundbreaking results from the phase III OptiTROP-Breast01 study of China’s first original TROP2 ADC, LuKangsa-Tropozumab (SKB264). This…
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EASL 2024 Hot Review | Professor Hai Li: The Role of Immunosuppression and Microbiome Variations in Liver Disease Progression
Acute-on-chronic liver failure (ACLF) is a complex syndrome characterized by acute deterioration of liver function in patients with chronic liver disease, accompanied by high mortality rates due to liver and extrahepatic organ failure. The short-term mortality rate of medical comprehensive treatment for ACLF can reach 50% to 90%. Given the high mortality and complex pathogenesis,…
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Five-Year Follow-Up Results of CD19 and CD22 CAR-T Combined Therapy for Relapsed B-ALL Post-Allogeneic Hematopoietic Stem Cell Transplantation
The 29th Annual Meeting of the European Hematology Association (EHA 2024) will be grandly held in Madrid, Spain, from June 13 to 16, 2024! As an international event in the field of hematology, EHA 2024 gathers top hematology experts worldwide to share and discuss the latest research findings in hematology. This issue features a research…
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Professor Wenyan Chen: Perseverance and Commitment—10-Year Follow-Up Results of the Phase III PANTHER Trial
Numerous studies have confirmed the clinical value of postoperative adjuvant chemotherapy for early-stage breast cancer patients. However, the cardiotoxicity and hematologic adverse reactions associated with high-dose chemotherapy remain significant clinical challenges. Recently, the ESMO BC 2024 conference released the 10-year follow-up results of the PANTHER trial, an important study on the treatment of high-risk early…
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Professor Junlong Zhuang: Interim Analysis Results of the PROact Study Further Support Combined Therapy for mHSPC Patients with HRR Gene Mutations
Studies have found that metastatic hormone-sensitive prostate cancer (mHSPC) patients with homologous recombination repair (HRR) gene mutations progress to metastatic castration-resistant prostate cancer (mCRPC) more quickly, significantly affecting overall survival. Previous research has shown that the combination of olaparib with abiraterone and prednisone significantly improves survival in mCRPC patients. At this year’s ASCO Annual Meeting,…
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