• Blood Science Update: New Insights into the Endothelial Origin of the Hematopoietic System

    This article, published in the journal Blood Science, elucidates groundbreaking advancements in understanding the endothelial origins of the hematopoietic system. As a leading platform in clinical and experimental hematology, Blood Science continues to publish high-impact research that transforms molecular biology and physiology. Authored by Professor Yu Lan from the Key Laboratory for Regenerative Medicine of…

  • Major Trial Challenges Role of Auto-HCT in Mantle Cell Lymphoma

    New findings from the ECOG-ACRIN EA4151 Phase 3 trial, published in Blood on November 25, 2024, could change clinical practice for mantle cell lymphoma (MCL).For years, autologous hematopoietic cell transplantation…

  • Major Trial Challenges Role of Auto-HCT in Mantle Cell Lymphoma

    New findings from the ECOG-ACRIN EA4151 Phase 3 trial, published in Blood on November 25, 2024, could change clinical practice for mantle cell lymphoma (MCL).For years, autologous hematopoietic cell transplantation…

  • Blood Science Update: The Dual Role of BCL11B in T-Cell Malignancies

    Blood Science continues to lead the way in elucidating  complex biological processes and their implications in disease. In this insightful review article, “Dual role of BCL11B in T-cell malignancies,” Grzegorz K. Przybylski, Julia Przybylska, and Yangqiu Li explore the paradoxical functions of the B-cell CLL/lymphoma 11B (BCL11B) gene in T-cell development and malignancies.

  • KEYMAKER-U03 Study: Advancing Immunotherapy in ccRCC

    The KEYMAKER-U03 Substudy 03B evaluated pembrolizumab-based immunotherapy combinations in advanced clear cell renal cell carcinoma (ccRCC) after progression on PD-(L)1 and VEGF-TKI therapies.Results show that pembrolizumab + quavonlimab (anti-CTLA-4) and…

  • Blood Science Update: Versatility of Megakaryocytes in Health and Disease

    This article, published in the esteemed journal Blood Science, explores the remarkable adaptability of megakaryocytes (MKs) in various physiological and pathological processes. Renowned for its pioneering work in hematology, Blood Science has showcased groundbreaking insights into the dynamic roles of MKs beyond their traditional function in platelet production, offering a deeper understanding of their involvement…

  • CALYPSO Study: Final Survival and ctDNA Analysis in MET-Driven Papillary Renal Cancer

    The CALYPSO study offers valuable insights into the effectiveness of durvalumab (PD-L1 inhibitor) plus savolitinib (MET inhibitor) (D+S) in MET-driven advanced papillary renal cancer (aPRC). At 41 months follow-up, MET-driven…

  • Plasma ctDNA vs Tumor Tissue Profiling in Biliary Tract Cancer: Insights from TOPAZ-1

    The TOPAZ-1 study has provided valuable insights into the role of plasma circulating tumor DNA (ctDNA) testing in detecting clinically actionable alterations (CAAs) in advanced biliary tract cancer (BTC). While…