UroStream

In this UroStream special from the 2025 EAU Congress, Professor Alicia K. Morgans from Dana-Farber Cancer Institute (USA) shares her expert insights into the evolving landscape of metastatic prostate cancer…

In recent years, the incidence of prostate cancer in China has continued to rise, creating an urgent need to improve diagnostic and treatment strategies tailored to this growing patient population. At the 5th Annual CUDA Yanqi Lake Meeting (2025), hosted by the Chinese Urological Doctor Association, UroStream invited Professor Liqun Zhou, Institute of Urology, Peking University, to discuss the importance of early screening, optimized diagnostic approaches, and advances in neoadjuvant therapy. His insights point toward practical steps for enhancing the survival and quality of life of prostate cancer patients in China.

At the 2025 Annual Meeting of the European Association of Urology (EAU), Professor Renée C.A. Leenen from Erasmus MC in Rotterdam, the Netherlands, presented the latest 20-year follow-up results from…

In a landmark advancement in xenotransplantation, the team at Xijing Hospital of the Air Force Medical University has achieved a major scientific milestone. Under the guidance of Academician Kefeng Dou…

For many years, systemic treatment of locally advanced or metastatic urothelial carcinoma has relied primarily on platinum-based chemotherapy. However, the recently reported EV-302 study has disrupted the traditional treatment paradigm.…

Presented at the 40th Annual EAU Congress, the ARANOTE study offered valuable post hoc insights into the significance of PSA response in patients with metastatic hormone-sensitive prostate cancer (mHSPC) treated…

From April 11 to 13, 2025, the 5th Chinese Urological Doctor Association Yanqi Lake Meeting—jointly organized by the Chinese Medical Doctor Association and Chinese Urological Doctor Association—was successfully held in Beijing. The event brought together prominent experts from across the country to explore the future of urology in China. UroStream invited Professor Nianzeng Xing, President of the Chinese Urological Doctor Association and expert from the Cancer Hospital, Chinese Academy of Medical Sciences, to discuss the meeting highlights, the importance of multidisciplinary collaboration, and efforts to improve care in grassroots hospitals.

Currently, ADT remains the cornerstone treatment regimen for mHSPC. However, long-term use of ADT may increase the risk of cardiovascular events. Recently, the data from the STAMPEDE study presented at the European Association of Urology (EAU) Congress showed that the combination of metformin and ADT can extend the overall survival of patients with high tumor burden mHSPC by 10 months (hazard ratio [HR] = 0.79). At the same time, it can also improve metabolic indicators: there is less weight gain (2.5 kg vs 4 kg) and a lower incidence of metabolic syndrome (4.9% vs 9.4%). UroStream specially invited the study presenter, Dr. Ashwin Sachdeva, a senior clinical lecturer in University of Manchester, Division of Cancer Sciences, to share the wonderful content on-site.

Bladder cancer is a biologically heterogeneous disease, and its classification plays a critical role in guiding treatment. However, current bladder cancer classification remains based primarily on clinical-pathological features or staging, with molecular subtyping yet to be standardized. At the 2025 European Association of Urology (EAU) Congress, Dr. Jeffrey S. Damrauer from the UNC Lineberger Comprehensive Cancer Center shared key insights on the response of different bladder cancer types to treatment, the role of neoadjuvant therapy, and the growing possibilities of bladder-sparing strategies.

For patients with non-muscle-invasive bladder cancer (NMIBC) who do not respond to Bacillus Calmette-Guérin (BCG) therapy, clinicians and researchers are actively exploring novel treatment strategies. Among these, oncolytic virus therapy has emerged as a promising approach. At the 40th Annual EAU Congress, Dr. Siamak Daneshmand from the University of Southern California (USC) presented two key studies on oncolytic viruses—the BOND-003 P cohort and the PIVOT-006 trial. UroStream invited Professor Daneshmand to discuss the mechanism of action, safety, efficacy, and future directions of this innovative therapy.