ASCO 2025 | Dr. Yan Huang’s Team Reports Phase I Results of BL-B01D1, Paving a New Path in Precision Treatment for SCLC
Small cell lung cancer (SCLC), often known as the “king of lung cancer,” has long relied on the EP regimen (cisplatin plus etoposide) as the foundation of first-line therapy for nearly three decades. Although recent years have seen the introduction of immunotherapy combined with chemotherapy, which has brought incremental survival benefits, long-term outcomes for patients remain limited. At the 2025 ASCO Annual Meeting, Dr. Yan Huang from Sun Yat-sen University Cancer Center presented the results of a Phase I study (Abstract #3002) on BL-B01D1, a bispecific antibody-drug conjugate (ADC) targeting EGFR and HER3, in patients with SCLC who had failed standard treatments. The study showed that in patients who progressed after first-line chemo-immunotherapy, BL-B01D1 achieved a median overall survival (OS) of 15.1 months and a confirmed objective response rate (ORR) of 75%—breakthrough data that may offer a potential new treatment option for this hard-to-treat disease. Oncology Frontier invited Dr. Huang to provide an in-depth interpretation of the study’s clinical significance and application prospects.
