IOncology

During the second Presidential Symposium at the 2024 World Conference on Lung Cancer (WCLC), Professor Jing-Ji Yang from Guangdong Provincial People’s Hospital presented the report “Osimertinib with or without Savolitinib as First-Line Treatment for De Novo MET Aberrant, EGFRm Advanced Non-Small Cell Lung Cancer (NSCLC) (CTONG 2008): Results from the Phase II FLOWERS Clinical Trial.”

The 2024 European Society for Medical Oncology (ESMO) Congress took place from September 13 to 17 in Barcelona, Spain, where significant progress in lung cancer research was unveiled. Dr. Ben J. Solomon, from the Peter MacCallum Cancer Centre in Melbourne, Australia, shared the results of the biomarker analysis from the ALINA study. In an exclusive interview with Oncology Frontier, Professor Solomon discussed the efficacy, safety, and biomarker analysis of alectinib in ALK-positive non-small cell lung cancer (NSCLC) patients. He also highlighted the latest advancements in targeted therapies for ALK-positive and KRAS G12C-mutant NSCLC.

Ilourac (WX-0593) is a next-generation, potent anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitor (TKI), showing both systemic and central nervous system (CNS) efficacy in patients with ALK-positive non-small cell lung cancer (NSCLC). At the 2024 ESMO Congress, updated data from the INSPIRE study were presented in a poster session, showing continued progression-free survival (PFS) improvement with ilourac compared to crizotinib in advanced ALK-positive and ALK TKI-naive NSCLC patients. Safety findings were consistent with previous results, with no new safety concerns observed. In this article, Oncology Outlook invited Dr. Xiao Chen from The First Bethune Hospital of Jilin University to provide commentary on the updated data from this study (Abstract #1278P).

The 2024 European Society for Medical Oncology (ESMO) Annual Meeting has successfully concluded. Several studies presented during the neuroendocrine tumor (NET) oral sessions have offered new treatment strategies and molecular profiling for advanced unresectable NETs. Notably, the Phase III CABINET study on cabozantinib achieved its primary endpoint of progression-free survival (PFS), and the multi-center single-arm CVM-005 study showed impressive PFS results with the anti-vasculogenic mimicry drug CVM-1118, especially when combined with SSA (somatostatin analogs), with the median PFS for extra-pulmonary NETs reaching nearly two years. Furthermore, multi-omics profiling has provided a foundation for prognostic assessment, classification-based treatment, and biomarker exploration in NETs. Oncology Frontier invited Dr. Jie Chen from Fudan University Shanghai Cancer Center to introduce and comment on these studies.

The 2024 World Conference on Lung Cancer (WCLC) was held in San Diego from September 7-10, featuring major studies from Chinese scholars. Oncology Frontier had the opportunity to interview Dr. Baohui Han from Shanghai Chest Hospital, inviting her to interpret the results of the DUBLIN-3 and DURABLE clinical trials.

Thrilled to share our interview with Professor Guohong Han about the LEAP-012 study, which could revolutionize liver cancer treatment! Combining TACE with lenvatinib and pembrolizumab is showing incredible results for intermediate-stage liver cancer: 46.8% tumor response rate Progression-free survival boosted from 10 to 14.6 months

In a recent Media Medic interview, our colleague El Bachir MOURABIT had the privilege to speak with Dr. Fred Saad about breakthrough advancements in metastatic hormone-sensitive prostate cancer (mHSPC) treatment. Dr. Saad emphasized the importance of combining androgen deprivation therapy (ADT) with ARPIs like apalutamide, enzalutamide, or abiraterone for improved survival. He also shared promising results from the Phase 3 ARINOTE study, showcasing darolutamide with ADT as a safe and effective option, especially for patients who may not tolerate chemotherapy.

The International Association for the Study of Lung Cancer (IASLC), founded in 1974, has grown into a global organization with over 10,000 members from more than 100 countries and regions. In 2023, Dr. Caicun Zhou from Shanghai Pulmonary Hospital, Tongji University School of Medicine was elected as the IASLC President-Elect for 2023-2025 and will serve as IASLC President for 2025-2027. He is the first IASLC President from mainland China in the organization’s 50-year history. This year marks the 50th anniversary of IASLC, and at the 2024 World Conference on Lung Cancer (WCLC), Oncology Frontier had the opportunity to speak with Dr. Caicun Zhou about IASLC’s remarkable journey over the past five decades in leading the fight against thoracic cancers.

As we step further into the 21st century, the field of medicine has undergone tremendous changes. Among the many advancements, a generation of compassionate and skilled doctors has emerged, dedicated to the wellbeing of their patients and their nation. The phrase "a doctor's heart is like a parent's" perfectly captures this essence. In the Oncology Frontier series "In Conversation," we reflect on the past with renowned doctors, exploring the highs and lows of their medical journeys. In this edition, we are honored to have Dr. Jie Chen from Fudan University Shanghai Cancer Center share her story. Over the past 30 years, she has remained dedicated to her mission. With five major career transitions, she has continually embraced challenges, breaking new ground where none existed. In the virtually untouched field of neuroendocrine tumors (NEN) in China, she laid the foundation for the discipline and paved the way for future advancements.

The American Society for Radiation Oncology (ASTRO) Annual Meeting took place in Washington, D.C., from September 29,2024 to October 2,2024. As one of the most prestigious annual events in radiation oncology, ASTRO offers a platform to share the latest advances, focusing on radiotherapy as a primary treatment for various cancers, alongside key updates in technology and basic research.