IOncology

Precision treatment for HER2-positive breast cancer has long been a focal point and challenge in breast cancer research. Recently, the DTP study (Abstract No.: RF1-07), presented at the 2024 San Antonio Breast Cancer Symposium (SABCS), offers new insights into addressing this challenge. This study aims to explore the efficacy and safety of combining durvalumab immunotherapy with dual-targeted therapy in the neoadjuvant treatment of early-stage HER2-positive breast cancer. The goal is to discover new diagnostic and therapeutic directions for HER2-enriched breast cancer driven by precision medicine. Oncology Frontier invited Professor Feng Jin fromThe First Affiliated Hospital of China Medical University and Dr. Xiaoman Jiang from The Second Hospital of Jilin University to provide an in-depth analysis and commentary on the DTP study.

With continuous advancements in immunotherapy research, significant progress has been made in improving survival outcomes for patients with non-small cell lung cancer (NSCLC). Recently, based on the results of the KEYNOTE-671 study, the National Medical Products Administration (NMPA) approved the PD-1 inhibitor pembrolizumab for perioperative treatment in patients with resectable stage II, IIIA, and IIIB NSCLC. What is the clinical significance of this newly approved indication for perioperative treatment in NSCLC? What key considerations should clinicians focus on in practice? How will perioperative immunotherapy for NSCLC evolve in the future?

Breast cancer patients may experience overweight or obesity during treatment due to medication side effects and hormonal fluctuations. What impact does being overweight or obese have on patient prognosis? At the recent San Antonio Breast Cancer Symposium (SABCS), numerous new research findings, clinical practices, and treatment advancements were presented. One study from the Early Breast Cancer Trialists’ Collaborative Group (EBCTCG) analyzed the relationship between overweight/obesity and prognosis in early-stage breast cancer patients. Oncology Frontier invited Dr. Cuizhi Geng from The Fourth Hospital of Hebei Medical University to summarize this relationship and share clinical intervention strategies.

The 47th San Antonio Breast Cancer Symposium (SABCS) successfully concluded in San Antonio, USA. On December 11 (local time), during the second day of the conference, Academician Binghe Xu from the Cancer Hospital Chinese Academy of Medical Sciences delivered a significant presentation in the "General Session 1," unveiling the latest data from the PHILA study (Abstract No.: GS1-03). This nationwide, multicenter randomized controlled trial evaluated the remarkable efficacy of Pyrotinib combined with Trastuzumab and Docetaxel as a first-line treatment for HER2-positive advanced breast cancer. Results showed a striking progression-free survival (PFS) of 22.1 months in the Pyrotinib group, significantly longer than the 10.5 months in the HT group.Oncology Frontier interviewed Academician Binghe Xu on-site to gain in-depth insights into the latest PHILA study data and explore the profound impact of the Pyrotinib combination regimen on the treatment of HER2-positive breast cancer.

At the 2024 San Antonio Breast Cancer Symposium (SABCS), Dr. Icro Meattini from the University of Florence, Italy, presented significant findings from the EUROPA trial. This Phase III randomized controlled trial focused on women aged 70 and above with Stage I Luminal breast cancer. The study aimed to compare the effects of radiation therapy (RT) alone versus endocrine therapy (ET) alone on health-related quality of life (HRQoL) and ipsilateral breast tumor recurrence (IBTR). Oncology Frontier interviewed Dr. Icro Meattini to discuss the study design and future research directions.

The 14th Shanghai Urologic Oncology Academic Conference and the Annual Meeting of the Chinese Anti-Cancer Association Male Reproductive System Tumor Committee (CACA-GO) took place from December 6–8,2024 in Shanghai. The conference invited several internationally renowned experts in urologic oncology for academic lectures and surgical demonstrations.Dr. Stephen Freedland from Cedars-Sinai Medical Center in the United States delivered two impactful presentations titled “EMBARK and Something Related to BCR” and “Race and Prostate Cancer – Access to Care vs. Biology or Both?” In an interview with Urology Frontier, Dr. Freedland further discussed the latest progress in the treatment of biochemical recurrence (BCR) in prostate cancer and topics related to racial disparities in healthcare.

The 47th San Antonio Breast Cancer Symposium (SABCS) successfully took place in San Antonio, USA. As one of the largest and most prestigious scientific gatherings in breast cancer research, SABCS showcased the latest findings, clinical practices, treatment advances, and technological innovations over the past year. Among the presented studies, an oral presentation (GS3-05) analyzed the efficacy of neoadjuvant chemotherapy combined with atezolizumab, followed by adjuvant atezolizumab in triple-negative breast cancer (TNBC) patients. Oncology Frontier invited Dr. Ting Luo from the West China Hospital of Sichuan University to introduce this study and provide expert commentary.

At the 2024 San Antonio Breast Cancer Symposium (SABCS), a study led by Professor Noor Wortelboer from Erasmus University Medical Center in Rotterdam was presented during the "Poster Spotlight 2: Personalizing CDK 4/6 Inhibitor Therapy for Patients with Metastatic Breast Cancer: Survival, QOL, and Biomarkers" session. This research, based on the SONIA trial data, provided an in-depth analysis of health-related quality of life (HRQoL) outcomes in patients using CDK4/6 inhibitors (CDK4/6i) at different treatment lines. The findings offer crucial insights into how CDK4/6i impacts patients’ quality of life and serve as valuable guidance for optimizing treatment strategies in advanced breast cancer. Oncology Frontier invited Dr. Yan Xue from Xi’an International Medical Center Oncology Hospital to interpret and comment on the study's data.

The 47th San Antonio Breast Cancer Symposium (SABCS) recently concluded successfully in San Antonio, USA. SABCS is the world’s largest conference in the field of breast cancer, attracting more than 10,000 registered participants from 102 countries. Over four days, the conference featured thousands of keynote speeches and research abstracts. On December 11, during the second day of the conference, Nobel Laureate in Physiology or Medicine (2019) Professor William Kaelin delivered a highly acclaimed keynote address on the topic of "Tumor Genetics and Targeted Drug Development." Oncology Frontier had the privilege of interviewing Dr. Guojun Zhang from Yunnan Cancer Hospital for a comprehensive review and summary of this lecture.

The "2024 Cross-Strait Breast Cancer Forum," held alongside the 2024 Academic Annual Meeting of the Breast Disease Branch of the Fujian Medical Association, the 2024 Annual Meeting of the Oncology Physicians Branch of the Fujian Medical Doctor Association, and the Fujian Breast Cancer Prevention and Treatment Workshop, took place from December 13 to 15, 2024, in Fuzhou. The forum brought together renowned experts to discuss the latest advancements in breast cancer and oncology. Oncology Frontier interviewed the forum chair, Dr. Jian Liu from Fujian Cancer Hospital, who shared insights into the event's agenda and its key highlights.