IOncology

From September 13 to 17, 2024, the highly anticipated European Society for Medical Oncology (ESMO) Annual Meeting took place in Barcelona, Spain. At this prestigious event, three cutting-edge research projects led by Dr. Lin Shen from Peking Cancer Hospital were successfully selected for poster presentations, showcasing the remarkable contributions of Chinese scholars in the field of oncology. Dr. Lin Shen has always emphasized the importance of designing clinical research to solve practical clinical problems, and these three studies exemplify that scientific spirit in action. Oncology Frontier has meticulously compiled the core content of these posters to present readers with an academic feast and to share the latest advancements in oncology.

From August 2 to 4, 2024, the 7th Oncology Precision Diagnosis and Treatment and the 10th Breast Cancer Individualized Treatment Conference (COMB), hosted by the China Cancer Foundation and the Beijing Breast Disease Prevention and Treatment Society, took place in Beijing. This conference focused on the development of individualized precision treatment in the field of breast cancer in China. Dr. Jin Zhang from Tianjin Medical University Cancer Institute and Hospital chaired a session titled “New Concepts in Regional Management of Breast Cancer,” discussing the precise development of comprehensive regional treatment for breast cancer. At the conference, Oncology Frontier had the opportunity to interview Dr. Jin Zhang, who shared insights on the de-escalation in early breast cancer surgery and explored the current status of anti-HER2 therapy and its clinical practice in advanced breast cancer.

At the 2024 European Society for Medical Oncology (ESMO) Annual Congress, Dr. Hitomi Sakai from the Advanced Cancer Translational Research Institute in Japan reported on the significant efficacy of the OLZ-based triple therapy in preventing treatment-related nausea and vomiting (NV) in patients treated with T-DXd, providing an important reference for clinical practice. After the conference, Dr. Hitomi Sakai was interviewed by Oncology Frontier, where she introduced the research process and related results.

At the 2024 ESMO Congress, Dr. Peter Schmid from Barts Cancer Institute, Queen Mary University of London shared the overall survival data from the KEYNOTE-522 study with a follow-up of 75.1 months. The long-term follow-up results of the study showed that the combination of immunotherapy and chemotherapy significantly extended the event-free survival and overall survival of patients with triple-negative breast cancer, reducing the risk of recurrence and death. This breakthrough not only reaffirms the therapeutic position of immunotherapy in early triple-negative breast cancer but also points the way for further optimizing treatment plans in the future, bringing longer survival hopes for patients. Oncology Frontier specially invited Dr. Peter Schmid to share the relevant data.

Xiamen, China, September 25-29, 2024 — The 27th National Clinical Oncology Conference and the 2024 Academic Annual Meeting of the Chinese Society of Clinical Oncology (CSCO) commenced in Xiamen, embracing the theme "Patient-Centric, Shared Future." Jointly organized by the CSCO and the CSCO Foundation, the conference has brought together top experts and elites in oncology from both domestic and international fields to discuss the latest advancements, cutting-edge technologies, and future trends in cancer prevention and treatment.

In April 2024, the 115th Annual Meeting of the American Association for Cancer Research (AACR) was held in San Diego, USA. As a global bellwether for new cancer drug development, the AACR meeting showcased numerous cutting-edge research findings in the field of oncology. One such study, conducted by Dr. Lin Shen's team from Peking Cancer Hospital, evaluated camrelizumab combined with chemotherapy as a neoadjuvant treatment for resectable locally advanced esophageal squamous cell carcinoma (LA-ESCC). This single-center, randomized, Phase II trial was selected for poster presentation at the conference, and Oncology Digest - Digestive Oncology News has summarized the key findings for readers.

Dr. Jiafu Ji, Dr. Ziyu Li, and Dr.  Lin Shen from Peking Cancer Hospital have co-authored a research paper titled “Cadonilimab with chemotherapy in HER2-negative gastric or gastroesophageal junction adenocarcinoma: the phase 1b/2 COMPASSION-04 trial”, published online in Nature Medicine. The study addresses several critical clinical issues, such as the limited benefit of PD-1 monoclonal antibody treatment, the high incidence of adverse effects with PD-1 and CTLA-4 combination therapy, and the ineffectiveness of PD-1 combined with chemotherapy in patients with low or negative CPS scores. To tackle these challenges, the researchers innovatively employed a domestically developed PD-1/CTLA-4 dual-target antibody in the COMPASSION-04 study, marking the first clinical trial globally to evaluate this combination as a first-line treatment for advanced gastric cancer.

In June 2024, the 14th Annual Meeting of the Chinese Gastrointestinal Oncology Group (CGOG) and the Peking University Digestive Tumor Forum was held in Beijing. With the theme of "Innovation, Win-Win, Excellence," the conference focused on precision diagnosis and treatment, as well as translational research in digestive system tumors. It also covered the latest research progress and challenges in clinical practice. During the event, a reporter from Oncology Frontier conducted an exclusive interview with the conference chair, Dr. Lin Shen from Peking Cancer Hospital. Below is the interview for readers.

The 2024 European Society for Medical Oncology (ESMO) Annual Meeting recently concluded in Barcelona, Spain, bringing together the world's leading oncology experts. At this year's conference, Dr. Yuhong Zhou from Zhongshan Hospital, Fudan University, presented a phase II multicenter clinical trial that explored the efficacy and safety of surufatinib combined with gemcitabine in soft tissue sarcoma (STS) patients who had failed anthracycline chemotherapy or anlotinib monotherapy. The study offers new perspectives for clinical practice.