IOncology

Hormone receptor-positive (HR+) breast cancer accounts for about 70% of all breast cancers. With endocrine therapy as the foundation, chemotherapy, targeted therapy, novel antibody-drug conjugates (ADCs), and immune checkpoint inhibitors (ICIs) provide a wealth of treatment options for HR+ advanced breast cancer patients, also offering more potential combinations for clinical practice. In this "Man Talks Breast Cancer: ASCO Special," Professor Man Li's team from The Second Affiliated Hospital of Dalian Medical University has selected the latest ASCO studies on HR+ advanced breast cancer, covering topics such as cross-line treatment with CDK4/6 inhibitors, novel ADCs combined with ICIs, and comparing CDK4/6 inhibitors + ET with chemotherapy in premenopausal women. These can provide more valuable insights for clinical practice.

For patients with muscle-invasive bladder cancer (MIBC), when the tumor is large, deeply invasive, or has local lymph node metastasis, the radicality of whole bladder surgery can be affected. Neoadjuvant therapy can enhance the rate of radical resection by downstaging the tumor, and it has become a current research hotspot. At this year's ASCO Annual Meeting in Chicago, USA, a study led by Professor Hongqian Guo's team from Nanjing Drum Tower Hospital was selected, exploring a new neoadjuvant treatment strategy with toripalimab combined with chemotherapy for MIBC patients. "Oncology Frontier" invited Professor Shun Zhang from Nanjing Drum Tower Hospital to share the relevant content on-site.

Breast cancer is a malignant tumor that seriously threatens women's health. Neoadjuvant therapy is a crucial means to provide more surgical opportunities and pave the way for a cure. However, the pathological complete response (pCR) varies significantly with different molecular subtypes and treatment regimens, making it challenging to predict treatment efficacy early in neoadjuvant therapy for individual patients. From May 31 to June 4, 2024, the American Society of Clinical Oncology (ASCO) Annual Meeting was grandly held. At the meeting, Professor Kun Wang's team from Guangdong Provincial People's Hospital presented a study on a model called NeoMDSS, which predicts the effectiveness of neoadjuvant therapy for breast cancer based on MRI and other clinical pathological parameters. Oncology Frontier interviewed Professor Kun Wang to share the main results and clinical significance of this study.

The 60th American Society of Clinical Oncology (ASCO) Annual Meeting was held from May 31 to June 4, 2024, in Chicago, USA. During the meeting, Professor Binghe Xu from the Chinese Academy of Medical Sciences Cancer Hospital presented groundbreaking results from the phase III OptiTROP-Breast01 study of China's first original TROP2 ADC, LuKangsa-Tropozumab (SKB264). This study, led by Professor Xu, primarily targeted advanced triple-negative breast cancer (TNBC) in China and showed that LuKangsa-Tropozumab achieved a median progression-free survival (PFS) of 6.7 months, an objective response rate (ORR) of 45.4%, and a significant improvement in overall survival (OS), making it the current TROP2 ADC with the best mPFS for TNBC. In this edition of "ASCO Voice of China," Professor Ying Fan shares insights into this pioneering achievement

The 60th Annual Meeting of the American Society of Clinical Oncology (ASCO) was grandly held in Chicago, USA, from May 31 to June 4, 2024. As a premier global event, ASCO gathers oncology experts from around the world to discuss the latest advancements and future trends in the field. At this year's ASCO conference, several studies led by Professor Pei Dong from the Sun Yat-sen University Cancer Prevention and Treatment Center were selected, making a significant impact on the international stage. These studies not only represent new progress in the field of urologic oncology in China but also contribute to the global development of urologic oncology. "Oncology Frontier" has summarized these studies for our readers.

The 2024 American Society of Clinical Oncology (ASCO) Annual Meeting will be held in Chicago from May 31 to June 4, Eastern Time. One study on OBX-115, an engineered tumor-infiltrating lymphocyte (TIL) therapy, garnered widespread attention. This research focuses on patients with immune checkpoint inhibitor (ICI)-resistant metastatic melanoma. Unlike traditional TIL therapy, OBX-115 has a key advantage: it does not require high-dose interleukin-2 (IL-2) systemic treatment, reducing the toxicity risk for patients. Initial results indicate that OBX-115 performs well in both safety and efficacy, providing new hope for ICI-resistant melanoma patients.

Uveal melanoma (UM) is a severe ocular malignant tumor that threatens patients' vision and survival. Despite some progress in treatment methods in recent years, the survival rate of patients has not significantly improved due to the lack of effective drugs, especially those that inhibit metastasis. At the ongoing 2024 American Society of Clinical Oncology (ASCO) Annual Meeting, several rapid oral reports focused on the challenges of UM treatment and presented the latest research findings. Oncology Frontier has compiled relevant studies for readers.

With advancements in medical research and technology, new therapies for complex diseases like breast cancer are continually emerging. Dato-DXd, a novel antibody-drug conjugate (ADC), shows potential in the treatment of breast cancer. The I-SPY2.2 trial, presented at ASCO 2024, utilizes an innovative trial design to demonstrate the efficacy of Dato-DXd as a monotherapy in HR-HER2-negative breast cancer, particularly in TNBC patients and those with positive immune markers. Oncology Frontier interviewed Professor Jane Lowe Meisel from Emory University's Winship Cancer Institute to delve into the innovative I-SPY 2.2 trial and its implications for personalized neoadjuvant therapy in high-risk breast cancer patients.

At the 2024 American Society of Clinical Oncology (ASCO) annual meeting, a multi-center study led by Professor Jin Li from Shanghai GaoBo Oncology Hospital, China Pharmaceutical University, reported that utidelone demonstrated significant anti-tumor activity in various pre-treated advanced solid tumors, particularly in first-line treatment of advanced gastric cancer. Oncology Frontier invited Professor Jin Li to further interpret the study

As immunotherapy continues to make breakthroughs in treating malignant tumors, it has significantly improved the survival rates of melanoma patients. However, there remains an urgent need to develop new drugs and optimize immunotherapy strategies for patients resistant or intolerant to current treatments. At the ongoing 2024 American Society of Clinical Oncology (ASCO) Annual Meeting, several studies focused on new treatment strategies for immunotherapy-resistant melanoma patients. Oncology Frontier invited Professor Yu Chen from Fujian Cancer Hospital to analyze these cutting-edge studies, revealing the important roles and potential applications of new therapies in this challenging melanoma subtype.