Hematology Frontier

Editor's Note: At the 30th Annual Congress of the European Hematology Association (EHA) held in Milan, Italy, global hematology experts gathered to share cutting-edge research and clinical breakthroughs. The prestigious…

Acute myeloid leukemia, subtype M2b (AML-M2b), was first identified in 1959 by Professor Chongli Yang at the Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences (CAMS), based on clinical features, bone marrow morphology, and cytology. He termed it “subacute granulocytic leukemia.” In 1973, Rowley and colleagues abroad reported the same leukemia subtype through cytogenetic methods. By the late 1990s, the team led by Professor Jianxiang Wang demonstrated that the chromosomal translocation t(8;21) leads to rearrangement of the AML1 and ETO genes, producing the AML1-ETO (RUNX1::RUNX1T1) fusion gene—the molecular hallmark of AML-M2b. This marker has since been widely applied in differential diagnosis and minimal residual disease (MRD) monitoring.

The 54th Annual Scientific Meeting of the International Society for Experimental Hematology (ISEH 2025) will be held in Kumamoto, Japan, from September 24 to 27, 2025. One of the major…

Hematologic malignancies such as leukemia, lymphoma, and multiple myeloma remain among the most challenging cancers to treat due to high relapse rates and treatment resistance. Tumor necrosis factor-related apoptosis-inducing ligand…

Allogeneic stem cell transplantation (ASCT) is the most definitive curative strategy for patients with acute leukemia (AL), especially those with high relapse risk. Traditionally, the decision to proceed to transplant…

Primary vitreoretinal lymphoma (PVRL) is a rare but highly aggressive intraocular malignancy closely associated with primary central nervous system lymphoma (PCNSL). Characterized by vague symptoms and high rates of misdiagnosis,…

Acute myeloid leukemia (AML) is a heterogeneous hematologic malignancy characterized by clonal expansion of myeloid precursor cells. Cytarabine (Ara-C) remains a cornerstone of induction chemotherapy; however, primary and acquired resistance to Ara-C significantly limits its therapeutic efficacy. Emerging studies have suggested that immune checkpoint and receptor molecules may influence tumor chemosensitivity, yet the role of TREML2, a member of the TREM family, has remained largely unexplored in the AML context. This article, published in Blood Science, investigated TREML2 expression in AML and uncovered its role in modulating responsiveness to Ara-C.

ZNF618::NUTM1-rearranged B-cell lymphoblastic leukemia (B-ALL) is recognized as a rare but favorable subtype of pediatric leukemia. However, this new case report published in Blood Science challenges that prognostic certainty, documenting a 3-year-old patient whose disease proved resistant to conventional chemotherapy, multiple CAR-T therapies, and hematopoietic stem cell transplantation. The findings underscore the need to reassess expectations surrounding NUTM1 fusion-positive leukemias and investigate the biological complexity behind treatment failure.

Essential thrombocythemia (ET) is a common myeloproliferative neoplasm characterized by elevated platelet counts, thrombotic and hemorrhagic events, and significantly impaired quality of life. At the 2025 European Hematology Association (EHA)…

The 2025 European Hematology Association (EHA) Annual Congress was successfully held from June 12 to 15 in Milan, Italy. Marking the 30th anniversary of the EHA, this year’s congress stood out as a major milestone, drawing over 15,000 experts and scholars from around the world with its global impact and groundbreaking research highlights. During the event, Oncology Frontier – Hematology Frontier had the privilege of speaking with Professor Martin Dreyling, Chair of the EHA 2025 Scientific Program Committee (SPC) and a professor at LMU Munich, to explore the most transformative scientific advances presented at the meeting.