As the 2025 Annual Meeting of the National Comprehensive Cancer Network (NCCN) concluded, Oncology Frontier exclusively interviewed Dr. Wui-Jin Koh, Chief Medical Officer of NCCN, to decode the future trends in cancer care. From the application prospects of AI-assisted medical decision-making to the inclusive practice of decentralized clinical trials, from the systemic challenges of combating healthcare professionals' burnout to the ecological reconstruction of cancer patient care systems, Dr. Wui-Jin Koh’s insights not only reveal NCCN’s future directions but also provide valuable references for the global medical community.