Dr. Antonio González-Martín from the Cancer Center Clínica Universidad de Navarra in Spain presented the results of the phase III PRIMA/ENGOT-OV26/GOG-3012 study (abstract number LBA29) at the 2024 ESMO Congress. For patients with advanced ovarian cancer with homologous recombination deficiency (HRd), the possibility of progression-free survival after treatment with niraparib is twice that of placebo, although the study did not report long-term overall survival (OS) benefit. Oncology Frontier invited Dr.Antonio González-Martín on site to analyze the clinical significance of this research finding.

The CABINET study (abstract number 11410), presented at the 2024 European Society for Medical Oncology (ESMO) Congress (September 13-17, Barcelona), updated the latest results of cabozantinib versus placebo in the treatment of advanced neuroendocrine tumors (NETs) after progression following previous treatment. At the conference site, we specially invited the Principal Investigator, Dr. Jennifer Chan from the Dana-Farber Cancer Institute in Boston, to be interviewed by us on site.

Immunotherapy for advanced liver cancer has advanced rapidly and has become a standard first-line treatment. A HIMALAYA study presented at the 2024 European Society for Medical Oncology (ESMO) Congress (September 13-17, Barcelona) evaluated the new immunotherapy combination STRIDE—tremelimumab and durvalumab compared with sorafenib. Dr. Lorenza Rimassa, the Principal Investigator from Humanitas University in Italy, was interviewed by us on site.

We are pleased to share an expert discussion with Dr. Peter Schmid on the findings from the pivotal Keynote 522 trial. This landmark Phase 3 study investigates the impact of combining chemotherapy with immunotherapy (Pembrolizumab) in early-stage triple-negative breast cancer (TNBC). The trial’s results highlight a 34% reduction in the risk of death, marking a significant advancement in patient outcomes and offering new hope for TNBC treatment strategies.

In the past, there has been ongoing debate about the therapeutic value of radiotherapy in resectable gastric cancer. The TOPGEAR study presented at the 2024 European Society for Medical Oncology (ESMO) Congress (September 13-17, Barcelona) evaluated the comparison between preoperative chemoradiotherapy and perioperative chemotherapy alone. Dr. Trevor Leong, the Principal Investigator from the University of Melbourne in Australia, was interviewed by us on site.