From December 6–8, 2024, the ESMO Asia Annual Meeting was held in Singapore, presenting groundbreaking research in oncology. Among the key highlights was the DESTINY-Gastric06 (DG06) study, which sparked extensive discussion. Oncology Frontier invited Prof. Zhi Peng, a leading researcher and specialist from Peking University Cancer Hospital, to share the latest findings from the DG06 study and insights into the role and future potential of antibody-drug conjugates (ADCs) in cancer treatment.

The 47th San Antonio Breast Cancer Symposium (SABCS), held from December 10–13, 2024, in San Antonio, USA, showcased the latest breakthroughs in breast cancer research, clinical practices, and technological innovations. This edition of "SABCS Broadcast" is hosted by Prof. Yongmei Yin from Jiangsu Provincial People’s Hospital, with live reporting by Prof. Junjie Li from Fudan University Shanghai Cancer Center. The discussion highlights the joint analysis of NRG Oncology/RTOG 9804 and ECOG-ACRIN E5194 on tamoxifen (TAM) use in low-risk ductal carcinoma in situ (DCIS), findings from the INSEMA trial on avoiding sentinel lymph node biopsy (SLND) in breast-conserving surgery patients, and the application of artificial intelligence (AI) in breast cancer risk screening.

At the 2024 European Society for Medical Oncology Asia Congress (ESMO ASIA 2024), during the Preferred Oral Presentations on Thoracic Oncology, Professor Yilong Wu from Guangdong Provincial People's Hospital presented the positive results of the PACIFIC-5 Phase III trial (Abstract No: LBA6). This study evaluated the efficacy of durvalumab consolidation therapy in unresectable Stage III non-small cell lung cancer (NSCLC) patients who remained progression-free after concurrent (cCRT) or sequential chemoradiotherapy (sCRT). Oncology Frontier invited Prof. Wu to provide an in-depth interpretation of the findings and highlight key points from this landmark study.

Liquid biopsy is not a new concept in the field of breast cancer, but its clinical applications continue to evolve, requiring fresh insights into the technologies, terminology, biomarkers, and future directions. On Tuesday, December 10 (Central Time), during the "Educational Session 2: Liquid Biopsy: MRD, ctDNA, and Monitoring Response to Treatment" at the 2024 San Antonio Breast Cancer Symposium (SABCS), experts discussed current liquid biopsy technologies and their optimal applications, including early disease detection, real-time monitoring, and predicting treatment responses.

Pathogenic germline mutations in certain genes are known to increase the risk of hereditary breast cancer. Approximately 5% to 10% of all breast cancer cases are hereditary, primarily driven by such mutations, with BRCA1/2 being the most common. Germline mutations also guide treatment decisions, as patients with pathogenic BRCA1/2 germline mutations may benefit from PARP inhibitor-based therapies.

On September 19, 2024, a randomized, double-blind, parallel-controlled, multicenter phase III clinical study, co-led by Professor Shukui Qin from the Nanjing Tianyinshan Hospital Affiliated to China Pharmaceutical University and Professor Liwei Wang from the Renji Hospital, Shanghai Jiaotong University School of Medicine, was published in Signal Transduction and Targeted Therapy (IF = 40.8), a prestigious international medical journal under Nature. The study evaluated the efficacy of irinotecan liposome (II) combined with 5-FU/LV as second-line treatment for locally advanced or metastatic pancreatic cancer after failure of gemcitabine therapy. Our results showed that the irinotecan liposome (II) combination therapy reduced the risk of death by 37% compared to the control group. Based on this research, irinotecan liposome (II) combination therapy was included as a Grade I expert recommendation (IA evidence) in the 2024 edition of the Chinese Society of Clinical Oncology Pancreatic Cancer Diagnosis and Treatment Guidelines. This treatment regimen fills the gap in second-line therapy for locally advanced or metastatic pancreatic cancer patients in China.

From December 10–13, 2024, the 47th San Antonio Breast Cancer Symposium (SABCS) took place in San Antonio, USA. As one of the largest and most prestigious gatherings in breast cancer research, SABCS showcased cutting-edge developments from the past year, including research breakthroughs, clinical practice insights, treatment advances, and technological innovations. Among these, studies led or co-authored by Dr. Jian Zhang’s team from Fudan University Shanghai Cancer Center were prominently featured. Following the conference, Oncology Frontier invited Dr. Jian Zhang to share insights from their team’s research.

Treatment strategies for HR+/HER2+ breast cancer have long been a focus of research. On December 11 (Central Time), during the 47th San Antonio Breast Cancer Symposium (SABCS), the results of the TOUCH study (Abstract RF1-02) were released, drawing significant attention. This international, open-label Phase II trial explored the efficacy of a chemotherapy-free approach in the neoadjuvant treatment of early HR+/HER2+ breast cancer. Dr. Feng Jin (The First Hospital of China Medical University), Dr. Diandong Zhang (Zhongshan Hospital, Dalian University), and Dr. Xinmiao Yu (The First Hospital of China Medical University) were invited to provide in-depth commentary on the study.

Global breast cancer researchers are tackling cutting-edge questions to inform clinical trial design and guide future treatment decisions. At the 2024 San Antonio Breast Cancer Symposium (SABCS), an internationally renowned panel of experts explored two of the most pressing topics in translational medicine—how to define triple-negative breast cancer (TNBC) and the development of tumor-agnostic therapies.