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Trastuzumab Deruxtecan Shows Intracranial Activity in HER2-Positive Breast Cancer with Active Brain Metastases
A patient-level pooled analysis combining the DEBBRAH and TUXEDO-1 trials along with the DFCI/Duke/MDACC cohort, published in ESMO Open (January 3, 2025), demonstrated clinically meaningful intracranial efficacy of trastuzumab deruxtecan…
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Blood Science Update| MicroRNAs: Discovery, Breakthrough, and Innovation
Historical Foundations and Discovery The origins of miRNA research trace back to the early 1990s, when Ambros and Ruvkun, both postdoctoral fellows in H. Robert Horvitz’s laboratory at MIT, investigated…
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Blood Science Update| Mitochondrial Genetic Variations in Leukemia: A Comprehensive Overview
Mitochondrial Genetics: A Distinct Layer of Complexity Mitochondria, as essential energy-generating organelles, possess a compact 16.5 kb circular genome encoding 37 genes critical for oxidative phosphorylation. Unlike nuclear DNA, mtDNA…
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Blood Science Update |Pre-Transplantation KMT2A-PTD Levels Predict Relapse in AML After Haploidentical HSCT
Study Design and Methods This single-center retrospective study analyzed 64 AML patients with KMT2A-PTD positivity at diagnosis who underwent HID HSCT between April 2016 and December 2020. Based on their…
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Blood Science Update|γδ T Cells in Hematological Malignancies: Mechanisms and Therapeutic Strategies
Study Focus and Methods The authors conducted a comprehensive synthesis of existing literature, experimental data, and ongoing clinical trials to evaluate the roles of γδ T cell subsets in antitumor…
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CUDA Yanqi Lake Meeting | Prof. Nianzeng Xing: Advancing Urology in China Through Multidisciplinary Collaboration
From April 11 to 13, 2025, the 5th Chinese Urological Doctor Association Yanqi Lake Meeting—jointly organized by the Chinese Medical Doctor Association and Chinese Urological Doctor Association—was successfully held in Beijing. The event brought together prominent experts from across the country to explore the future of urology in China. UroStream invited Professor Nianzeng Xing, President…
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Blood Science Update|In Vitro Erythropoiesis: The Emerging Potential of Induced Pluripotent Stem Cells (iPSCs)
Despite over 100 million units of blood being donated annually, supply remains insufficient, particularly for patients with chronic conditions or in crisis settings. Alloimmunization and blood group incompatibilities further constrain transfusion efficacy. In response, researchers are exploring the use of induced pluripotent stem cells (iPSCs) to generate red blood cells (RBCs) in vitro as a…
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Blood Science Update|Enhancing Hemophilia A Gene Therapy: Strategic F8 Deletions in AAV8 Vectors
Hemophilia A is a chronic bleeding disorder resulting from a deficiency in coagulation factor VIII (F8). Current treatment strategies rely on frequent F8 replacement therapy, which is limited by its short half-life, high cost, and the risk of inhibitor development. Gene therapy using adeno-associated virus serotype 8 (AAV8) has emerged as a promising modality, offering…
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