-
Dr. Minghua Zheng’s Team: AI-Based Digital Pathology Provides New Insights into NASH Fibrosis Reversal Induced by Lifestyle Intervention
Non-Alcoholic Steatohepatitis (NASH) is a common cause of chronic liver disease, and the degree of liver fibrosis is an important factor determining its clinical prognosis. Lifestyle intervention is the cornerstone of NASH treatment and can improve liver fibrosis. However, the specific effects of lifestyle intervention on micro-level liver fibrosis reversal are not clear. Dr. Minghua…
-
Tumor Cell-Released Kynurenine Biases MEP Differentiation into Megakaryocytes in Individuals with Cancer: A Novel Mechanism for Thrombocytosis and Erythrocytopenia
Thrombocytosis and erythrocytopenia are common hematological abnormalities observed in individuals with advanced cancer. However, the underlying molecular mechanisms for these conditions remain largely unknown. In this study, we aimed to…
-
Targeting Gut Microbial Nitrogen Recycling for Bortezomib Resistance in Multiple Myeloma
Multiple myeloma (MM) is a challenging hematological malignancy characterized by the proliferation of malignant plasma cells. Drug resistance and relapse remain major obstacles in the treatment of MM, emphasizing the…
-
Deciphering STING-Driven Platelet Activation in Septic Thrombosis: A Comprehensive Study Unveiling Molecular Mechanisms and Therapeutic Avenues
Sepsis, a life-threatening condition marked by an overwhelming immune response to infection, often leads to severe complications, including septic thrombosis. Recent studies have uncovered the involvement of the STING (Stimulator…
-
Single-Cell Dissection of Human Hematopoietic Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation
Hematopoietic stem cell transplantation (HSCT) is a regenerative therapy used to treat various malignant, inherited, or autoimmune diseases. Despite its success, the understanding of hematopoietic reconstitution in transplant patients remains…
-
The Complexity of Diffuse Large B-Cell Lymphoma: A Revolutionary Genetic Subtyping Algorithm
Diffuse large B-cell lymphoma (DLBCL), the most prevalent subtype of non-Hodgkin’s lymphoma, presents a significant challenge in its treatment due to its molecular heterogeneity. Despite advancements in immunochemotherapy, a substantial…
-
The Role of PD-1 Signaling in T-Cell Acute Lymphoblastic Leukemia: A Revolutionary Breakthrough
T-cell acute lymphoblastic leukemia (T-ALL) emerges as a formidable adversary within the spectrum of blood cancers, marked by the rapid proliferation of immature T-cell progenitors. The imperative to unravel the…
-
Multi-Omics Blood Atlas Reveals Unique Features of Immune and Platelet Responses to SARS-CoV-2 Omicron Breakthrough Infection
The COVID-19 pandemic caused by SARS-CoV-2 has affected millions of people worldwide. The emergence of new variants, such as Omicron, has raised concerns about the effectiveness of immune responses and…
Connecting Medical Expertise through Media