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Blood Science Update|A Prognostic Analysis of Acute Leukemia Patients With Prior CNS Involvement Undergoing Umbilical Cord Blood Transplantation
Published in Blood Science in 2025, the study led by Zichang Shen examines the impact of central nervous system leukemia (CNSL) on outcomes after umbilical cord blood transplantation (UCBT). CNSL remains a difficult manifestation of acute leukemia because leukemic cells within the CNS can evade systemic chemotherapy and drive relapse. Although allogeneic transplantation is the most effective curative approach for high-risk disease,…
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CCHIO 2025丨Guojun Zhang: A Landmark Gathering of Experts Opening a New Chapter in Integrated Oncology Care
Editor’s Note: The 2025 China Conference on Holistic and Integrative Oncology (CCHIO) was held in Kunming from November 6–9, 2025. The meeting was hosted by the China Anti-Cancer Association (CACA)…
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9th East China Breast Cancer Salon丨Wei Li: 2025 ESMO Highlights — ADCs Reshape Treatment Paradigms with Emerging Chinese Innovations
Editor’s Note: At the 2025 ESMO Annual Congress, the breast cancer field once again witnessed multiple breakthroughs—ranging from the DESTINY-Breast09 study, which redefined first-line therapy for advanced HER2-positive breast cancer,…
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Blood Science Update|Alpha-Enolase Drives AML Progression via MAPK/ERK Signaling: Condensed Summary
The commentary “Alpha-enolase promotes progression of acute myeloid leukemia via MAPK/ERK signaling pathway” by Zhang et al., published in Blood Science (2025), examines the clinical and biological significance of ENO1 in acute myeloid leukemia (AML). ENO1, a glycolytic enzyme with additional regulatory roles, has been implicated in several solid tumors, but its function in AML had not been fully clarified. Through integrated analyses of patient…
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9th East China Breast Cancer Salon丨Min Yan: Focusing on the TROP2 Target—Opening a New Chapter in Breast Cancer Therapy
Editor’s Note: The 2025 Second Forum on Innovative Anticancer Drug Clinical Research and the 9th East China Breast Cancer Salon, hosted by the Beijing Sci-Tech Medical Development Foundation and organized…
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Blood Science Update | Unrelated Cord Blood as a Source of Stem Cells: Cryopreservation Damage Can Be Alleviated by Restoring Mitochondrial Function
Study Overview The investigators compared fresh UCB samples with cryopreserved units stored for up to 19 years, examining hematopoietic stem and progenitor cell (HSPC) function and mitochondrial health. Single-cell transcriptomic…
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Blood Science Update | Daratumumab in Children With Advanced Idiopathic Thrombocytopenic Purpura
Background Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder characterized by low platelet counts due to antibody-mediated destruction and impaired platelet production. Although most children respond to first-line treatments such…
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Blood Science Update | A Promising Leap in Treating Large Granular Lymphocytic Leukemia with Thalidomide-Based Therapy
Background Large granular lymphocytic leukemia (LGLL) is an uncommon clonal lymphoproliferative disorder marked by the expansion of cytotoxic CD8⁺ T cells (T-LGLL) or NK cells (NK-LGLL), accounting for 2–6% of…
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