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CheckMate 8HW: Dual Immunotherapy Improves Outcomes in MSI-H/dMMR mCRC
At ASCO GI 2025, Thierry André and colleagues presented CheckMate 8HW results, showing nivolumab (NIVO) + ipilimumab (IPI) outperforms NIVO alone in MSI-H/dMMR metastatic colorectal cancer (mCRC). Key findings:✅ PFS…
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BREAKWATER Trial: Advancing First-Line Therapy for BRAF V600E-Mutant Colorectal Cancer
A new phase 3 study, led by Scott Kopetz and an international team, provides strong evidence supporting encorafenib + cetuximab (EC) with mFOLFOX6 as a first-line treatment for BRAF V600E-mutant…
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Yelena Janjigian Leads Advances in HER2+ Gastroesophageal Cancer Treatment
At ASCO GI 2025, Yelena Janjigian and colleagues presented DESTINY-Gastric03 (DG-03) trial results, evaluating trastuzumab deruxtecan (T-DXd) with fluoropyrimidine (FP) and pembrolizumab as first-line therapy for advanced HER2+ gastric, esophageal,…
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Anna Martling’s Research on Aspirin as an Adjuvant Therapy in Colorectal Cancer
A recent study led by Anna Martling, the ALASCCA trial, provides new evidence that low-dose aspirin (160 mg daily) can reduce recurrence risk in colorectal cancer (CRC) patients with PI3K…
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2025 CASH丨Dr. Yongrong Lai: Advances in Gene Therapy for Thalassemia
Thalassemia, an inherited blood disorder, imposes a significant economic and resource burden on patients, families, and society at large. In recent years, advances in medical research have led to a growing range of treatment options for thalassemia, including traditional blood transfusions and iron chelation therapy, drugs to induce gamma-globin production, hematopoietic stem cell transplantation (HSCT),…
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ASH 2024 | Dr. Neha Mehta-Shah Discusses Challenges and Innovations in T-Cell Lymphoma Treatment
Significant progress has been made in the treatment of T-cell lymphomas in recent years. However, challenges persist in managing relapsed/refractory disease, selecting optimal therapies, and determining the best treatment sequencing for patients. To address these issues, the 2024 American Society of Hematology (ASH) Annual Meeting featured an educational session titled Addressing Unmet Needs in T-Cell…
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Annual Review | Dr. Dingwei Ye: Key Advances in Systemic Therapy for Advanced Prostate Cancer
Prostate cancer is one of the most common malignancies affecting the male genitourinary system, and in China, a significant proportion of newly diagnosed patients present with advanced disease. Since late-stage prostate cancer is symptomatic and not curable, alleviating symptoms, delaying disease progression, and improving quality of life have always been priorities for both patients and…
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Emerging CAR-T Therapies: A Breakthrough in Treating Gastrointestinal Cancers
CAR-T Therapy in GI Cancers Adoptive T-cell therapies, including CAR-T, TCR-T, and tumor-infiltrating lymphocyte (TIL) therapies, are being explored for their potential to improve outcomes in GI cancers. CAR-T therapy,…
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