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Blood Science Update: The Dual Role of BCL11B in T-Cell Malignancies
Blood Science continues to lead the way in elucidating complex biological processes and their implications in disease. In this insightful review article, “Dual role of BCL11B in T-cell malignancies,” Grzegorz K. Przybylski, Julia Przybylska, and Yangqiu Li explore the paradoxical functions of the B-cell CLL/lymphoma 11B (BCL11B) gene in T-cell development and malignancies.
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KEYMAKER-U03 Study: Advancing Immunotherapy in ccRCC
The KEYMAKER-U03 Substudy 03B evaluated pembrolizumab-based immunotherapy combinations in advanced clear cell renal cell carcinoma (ccRCC) after progression on PD-(L)1 and VEGF-TKI therapies.Results show that pembrolizumab + quavonlimab (anti-CTLA-4) and…
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Blood Science Update: Versatility of Megakaryocytes in Health and Disease
This article, published in the esteemed journal Blood Science, explores the remarkable adaptability of megakaryocytes (MKs) in various physiological and pathological processes. Renowned for its pioneering work in hematology, Blood Science has showcased groundbreaking insights into the dynamic roles of MKs beyond their traditional function in platelet production, offering a deeper understanding of their involvement…
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CALYPSO Study: Final Survival and ctDNA Analysis in MET-Driven Papillary Renal Cancer
The CALYPSO study offers valuable insights into the effectiveness of durvalumab (PD-L1 inhibitor) plus savolitinib (MET inhibitor) (D+S) in MET-driven advanced papillary renal cancer (aPRC). At 41 months follow-up, MET-driven…
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Plasma ctDNA vs Tumor Tissue Profiling in Biliary Tract Cancer: Insights from TOPAZ-1
The TOPAZ-1 study has provided valuable insights into the role of plasma circulating tumor DNA (ctDNA) testing in detecting clinically actionable alterations (CAAs) in advanced biliary tract cancer (BTC). While…
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Throwback to SABCS 2024: Dr. Matteo Lambertini on Risk-Reducing Surgery in Young BRCA Carriers
At SABCS 2024, Dr. Matteo Lambertini shared insights from a major international study examining the role of risk-reducing mastectomy (RRM) and salpingo-oophorectomy (RRSO) in young BRCA carriers with breast cancer. The study, which analyzed data from 5,290 patients across 109 centers worldwide, offers a deeper understanding of how these surgeries impact long-term survival.
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Throwback to SABCS 2024: Rethinking Postmastectomy Radiotherapy – Insights from Prof. Ian Kunkler
At SABCS 2024, Professor Ian Kunkler presented the 10-year results of the SUPREMO trial, a phase III study evaluating the role of postmastectomy radiotherapy (PMRT) in intermediate-risk breast cancer. The trial aimed to determine whether PMRT improves overall survival in patients with 1-3 positive lymph nodes or high-risk node-negative disease.
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Throwback to SABCS 2024: Dr. Icro Meattini on the EUROPA Trial – Optimizing Treatment for Older Women with Early Breast Cancer
At SABCS 2024, Dr. Icro Meattini presented a preplanned interim analysis of the EUROPA trial, a randomized phase III study comparing exclusive endocrine therapy (ET) vs. radiation therapy (RT) in women aged 70+ with luminal-like early breast cancer. The study aimed to evaluate quality of life (HRQOL) and ipsilateral breast tumor recurrence (IBTR) to guide…
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