IOncology

Clear cell renal cell carcinoma (ccRCC) is closely associated with dysregulation of the VHL pathway, leading to the overexpression of HIF-2α and activation of multiple oncogenic pathways. Targeting HIF-2α with therapies such as belzutifan has provided new hope for patients with VHL syndrome and even broader applications in kidney cancer treatment. At this year’s ASCO Genitourinary Cancers Symposium (ASCO GU), Urology Frontier invited Dr. Kan Gong from Peking University First Hospital to discuss with Dr. Eric Jonasch, Director of the VHL Clinical Center at MD Anderson Cancer Center, the patient populations benefiting from belzutifan, management of adverse effects, and its future clinical applications.

The KEYNOTE-522 trial, published in May 2024, highlights how pembrolizumab combined with chemotherapy improves event-free survival (EFS) in early-stage triple-negative breast cancer (TNBC), particularly across Residual Cancer Burden (RCB) categories.…

The RIGHT Choice trial, published in August 2024, evaluated the efficacy of ribociclib plus endocrine therapy (ET) versus combination chemotherapy (CT) as a first-line treatment in premenopausal women with clinically…

Immuno-oncology (IO) has revolutionized the treatment landscape for non-small cell lung cancer (NSCLC), providing durable responses and survival benefits across different disease stages. The success of immune checkpoint inhibitors (ICIs), including PD-(L)1 and CTLA-4 inhibitors, has paved the way for dual immune checkpoint blockade (ICB) therapy, aiming to enhance antitumor immunity. While clinical trials such as KEYNOTE-024 and KEYNOTE-189 have demonstrated significant benefits with ICI monotherapy or ICI combined with chemotherapy in advanced NSCLC, overcoming treatment resistance and improving five-year overall survival (OS) remain key challenges.

On May 20, 2024, Dr. Aditya Bardia and his colleagues published the final results of the Phase III ASCENT trial, reinforcing Sacituzumab Govitecan (SG) as a superior treatment option over…

In the evolving landscape of breast cancer treatment, the management of HR+ advanced breast cancer remains a central focus. During the Northern China Breast Cancer Salon – Annual Progress Review, Dr. Zhanhong Chen from Zhejiang Cancer Hospital delivered an in-depth analysis on the stratified treatment approach for HR+ advanced breast cancer. Following the meeting, Oncology Frontier invited Professor Chen to discuss key topics, including the optimal timing for CDK4/6 inhibitor use and the future development of novel targeted therapies.

As one of the most important academic conferences in the field of gastrointestinal oncology, the American Society of Clinical Oncology Gastrointestinal Cancers Symposium (ASCO GI) presents a wealth of early-phase drug development data, key registration studies, major research updates, and subgroup analyses every year. These findings represent the latest advancements in the diagnosis and treatment of gastrointestinal cancers. A Phase II multicenter randomized study led by Dr. Zhiqiang Wang from Sun Yat-sen University Cancer Center, which compared the efficacy and safety of albumin-bound docetaxel versus conventional docetaxel in previously treated patients with advanced gastric or gastroesophageal junction adenocarcinoma, was selected as an oral abstract (Abstract #333) at this year’s ASCO GI.

Editor's Note: in choosing CDK4/6 inhibitors for adjuvant intensified treatment in HR+/HER2- breast cancer patients, do you prefer abemaciclib or ribociclib? At the 2024 Breast Cancer Summer Forum·Northern Salon "In-Depth…

Editor's Note: On July 27-28, 2024, the "2024 Breast Cancer Summer Forum · Northern Salon" was grandly held at Beijing Shougang Park. The conference upheld the philosophy of "learning and…