IOncology

The 60th American Society of Clinical Oncology (ASCO) Annual Meeting was held from May 31 to June 4, 2024, in Chicago, USA. During the meeting, Professor Binghe Xu from the Chinese Academy of Medical Sciences Cancer Hospital presented groundbreaking results from the phase III OptiTROP-Breast01 study of China's first original TROP2 ADC, LuKangsa-Tropozumab (SKB264). This study, led by Professor Xu, primarily targeted advanced triple-negative breast cancer (TNBC) in China and showed that LuKangsa-Tropozumab achieved a median progression-free survival (PFS) of 6.7 months, an objective response rate (ORR) of 45.4%, and a significant improvement in overall survival (OS), making it the current TROP2 ADC with the best mPFS for TNBC. In this edition of "ASCO Voice of China," Professor Ying Fan shares insights into this pioneering achievement

The 60th Annual Meeting of the American Society of Clinical Oncology (ASCO) was grandly held in Chicago, USA, from May 31 to June 4, 2024. As a premier global event, ASCO gathers oncology experts from around the world to discuss the latest advancements and future trends in the field. At this year's ASCO conference, several studies led by Professor Pei Dong from the Sun Yat-sen University Cancer Prevention and Treatment Center were selected, making a significant impact on the international stage. These studies not only represent new progress in the field of urologic oncology in China but also contribute to the global development of urologic oncology. "Oncology Frontier" has summarized these studies for our readers.

The 2024 American Society of Clinical Oncology (ASCO) Annual Meeting will be held in Chicago from May 31 to June 4, Eastern Time. One study on OBX-115, an engineered tumor-infiltrating lymphocyte (TIL) therapy, garnered widespread attention. This research focuses on patients with immune checkpoint inhibitor (ICI)-resistant metastatic melanoma. Unlike traditional TIL therapy, OBX-115 has a key advantage: it does not require high-dose interleukin-2 (IL-2) systemic treatment, reducing the toxicity risk for patients. Initial results indicate that OBX-115 performs well in both safety and efficacy, providing new hope for ICI-resistant melanoma patients.

Uveal melanoma (UM) is a severe ocular malignant tumor that threatens patients' vision and survival. Despite some progress in treatment methods in recent years, the survival rate of patients has not significantly improved due to the lack of effective drugs, especially those that inhibit metastasis. At the ongoing 2024 American Society of Clinical Oncology (ASCO) Annual Meeting, several rapid oral reports focused on the challenges of UM treatment and presented the latest research findings. Oncology Frontier has compiled relevant studies for readers.

With advancements in medical research and technology, new therapies for complex diseases like breast cancer are continually emerging. Dato-DXd, a novel antibody-drug conjugate (ADC), shows potential in the treatment of breast cancer. The I-SPY2.2 trial, presented at ASCO 2024, utilizes an innovative trial design to demonstrate the efficacy of Dato-DXd as a monotherapy in HR-HER2-negative breast cancer, particularly in TNBC patients and those with positive immune markers. Oncology Frontier interviewed Professor Jane Lowe Meisel from Emory University's Winship Cancer Institute to delve into the innovative I-SPY 2.2 trial and its implications for personalized neoadjuvant therapy in high-risk breast cancer patients.

At the 2024 American Society of Clinical Oncology (ASCO) annual meeting, a multi-center study led by Professor Jin Li from Shanghai GaoBo Oncology Hospital, China Pharmaceutical University, reported that utidelone demonstrated significant anti-tumor activity in various pre-treated advanced solid tumors, particularly in first-line treatment of advanced gastric cancer. Oncology Frontier invited Professor Jin Li to further interpret the study

As immunotherapy continues to make breakthroughs in treating malignant tumors, it has significantly improved the survival rates of melanoma patients. However, there remains an urgent need to develop new drugs and optimize immunotherapy strategies for patients resistant or intolerant to current treatments. At the ongoing 2024 American Society of Clinical Oncology (ASCO) Annual Meeting, several studies focused on new treatment strategies for immunotherapy-resistant melanoma patients. Oncology Frontier invited Professor Yu Chen from Fujian Cancer Hospital to analyze these cutting-edge studies, revealing the important roles and potential applications of new therapies in this challenging melanoma subtype.

Brain metastasis from breast cancer has a high incidence, second only to lung cancer . Previous studies have shown that patients with brain metastases have poorer survival compared to those without brain metastases, with HER2-negative breast cancer brain metastasis patients having an even worse prognosis . Due to the blood-brain barrier (BBB), many drug treatments have limited intracranial objective response rates (ORR). Utidelone, a novel microtubule inhibitor developed in China, has shown potential for treating brain metastases due to its unique physicochemical properties that allow it to penetrate the BBB. At the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting, a multicenter phase II study led by Professor Min Yan from Henan Cancer Hospital was selected for presentation. This study explored the efficacy and safety of utidelone combined with bevacizumab in treating HER2-negative breast cancer brain metastases. "Oncology Frontier" invited Professor Min Yan to discuss the progress in treating breast cancer brain metastases, the study design and findings, and future perspectives.

As immunotherapy continues to make breakthroughs in treating malignant tumors, it has significantly improved the survival rates of melanoma patients. However, there remains an urgent need to develop new drugs and optimize immunotherapy strategies for patients resistant or intolerant to current treatments. At the ongoing 2024 American Society of Clinical Oncology (ASCO) Annual Meeting, several studies focused on new treatment strategies for immunotherapy-resistant melanoma patients. Oncology Frontier invited Professor Yu Chen from Fujian Cancer Hospital to analyze these cutting-edge studies, revealing the important roles and potential applications of new therapies in this challenging melanoma subtype.

The 2024 American Society of Clinical Oncology (ASCO) Annual Meeting was held in Chicago, USA, from May 31 to June 4. At this year’s ASCO conference, the TROPION-Breast01 study (Oral Abstract Session: Abstract No. 1006) once again attracted attention and discussion. Professor Sonia Pernas from the Institut Català d'Oncologia presented a special report on June 1 from 16:24 to 16:36 (Beijing time: June 2, 05:24 to 05:36, Hall B1 | Live Stream). "Oncology Frontier" invited Professor Peng Yuan from the Chinese Academy of Medical Sciences Cancer Hospital to interpret the findings.