ASCO China Voice | Academician Binghe Xu: China-Developed B7-H4 ADC Demonstrates Promising Antitumor Activity and Excellent Safety, Offering a Potential Breakthrough for Two Difficult-to-Treat Advanced Solid Tumors

ASCO China Voice | Academician Binghe Xu: China-Developed B7-H4 ADC Demonstrates Promising Antitumor Activity and Excellent Safety, Offering a Potential Breakthrough for Two Difficult-to-Treat Advanced Solid Tumors

The 2026 American Society of Clinical Oncology (ASCO) Annual Meeting, held from May 29 to June 2 in Chicago, USA, featured the first-in-human Phase 1a results (Abstract #3013) of BG-C9074, a novel B7-H4-targeting antibody-drug conjugate (ADC) developed in China, during the Rapid Oral Abstract Session on Developmental Therapeutics.
ASCO China Voice | Professors Jian Zhang and Wenxing Qin: Chinese-Developed Oral SERD TFX06 Demonstrates Promising Activity in Fulvestrant-Pretreated ER+/HER2− Advanced Breast Cancer

ASCO China Voice | Professors Jian Zhang and Wenxing Qin: Chinese-Developed Oral SERD TFX06 Demonstrates Promising Activity in Fulvestrant-Pretreated ER+/HER2− Advanced Breast Cancer

For patients with HR+/HER2− advanced breast cancer, fulvestrant combined with targeted therapy remains the preferred treatment after progression on aromatase inhibitors (AIs). However, for patients whose disease progresses following fulvestrant, there is currently no established standard of care worldwide.

Professor Yuwen Zhou: CAPCET Study Demonstrates a More Effective and Cost-Efficient First-Line Strategy for Left-Sided RAS/BRAF Wild-Type Metastatic Colorectal Cancer

Professor Yuwen Zhou will present the CAPCET study, which focuses on first-line treatment for patients with RAS/BRAF wild-type left-sided metastatic colorectal cancer. By comparing modified CAPOX plus cetuximab with the conventional mFOLFOX6-based regimen, the study demonstrated significant therapeutic advantages. The results showed superior progression-free survival (PFS), overall survival (OS), and objective response rate (ORR), while also offering reduced toxicity and better cost-effectiveness. These findings support the regimen as an efficient, safe, and economically favorable first-line treatment option for clinical practice.

Professor Haihong Wang: UNION TNT Study Highlights the Potential of Precision Combination Therapy for HER2-Expressing Locally Advanced Rectal Cancer

Professor Haihong Wang will present the UNION TNT study, which explores short-course radiotherapy combined with disitamab vedotin and immunochemotherapy for patients with HER2-expressing locally advanced rectal cancer. Preliminary findings demonstrate remarkable clinical benefit, with a pathological complete response (pCR) rate of 75% among patients who underwent surgery, while several additional patients achieved clinical complete response (cCR). These encouraging results underscore the significant potential of precision targeted combination therapy in the immunotherapy era to improve treatment efficacy while maximizing opportunities for organ preservation.

Professor Yi Yi Yu: Building a High-Quality IIT Research System at Zhongshan Hospital

This presentation provided an in-depth overview of Zhongshan Hospital's investigator-initiated trial (IIT) research system, highlighting its practical experience in infrastructure development, digital platforms, and talent cultivation. Through the implementation of the CREMS management platform, a dual electronic data capture (EDC) system, and the institutional innovation known as the "Zhongshan Ten Measures," the hospital has established a closed-loop quality management system covering the entire clinical research process. This model emphasizes standardized management spanning scientific review through to research translation, providing a robust foundation for medical innovation.
Pujiang Prostate Cancer Summit | Professor Jianming Guo: Breaking Through CRPC Resistance and Why Cytoreductive Surgery for Oligometastatic Disease Is Emerging as the Next Frontier

Pujiang Prostate Cancer Summit | Professor Jianming Guo: Breaking Through CRPC Resistance and Why Cytoreductive Surgery for Oligometastatic Disease Is Emerging as the Next Frontier

The 2026 Pujiang Prostate Cancer Summit was successfully held in Shanghai on June 26–27. Hosted by the Shanghai Anti-Cancer Association and organized by Fudan University Shanghai Cancer Center, the meeting brought together leading experts through keynote lectures, multidisciplinary (MDT) discussions, and live surgical demonstrations to highlight the latest advances in prostate cancer management. Among the meeting's major themes, personalized and precision treatment strategies attracted particular attention.
Pujiang Prostate Cancer Summit | Professor Dingwei Ye: Expanding Early Screening, Standardizing Care, and Advancing Clinical Research—Three Pillars to Narrow China’s Prostate Cancer Survival Gap

Pujiang Prostate Cancer Summit | Professor Dingwei Ye: Expanding Early Screening, Standardizing Care, and Advancing Clinical Research—Three Pillars to Narrow China’s Prostate Cancer Survival Gap

The 2026 Pujiang Prostate Cancer Summit was held in Shanghai on June 26–27 under the theme "Standardization, Precision, Chinese Innovation, and Global Collaboration." The meeting brought together leading experts in genitourinary oncology to showcase the latest advances in standardized prostate cancer management and innovative treatment strategies.
Clear Horizons, Comprehensive Urologic Care | Professor Xin Yao: ADT Remains the Cornerstone of Prostate Cancer Management, While LHRH Antagonists Deliver Both Clinical Efficacy and Quality of Life

Clear Horizons, Comprehensive Urologic Care | Professor Xin Yao: ADT Remains the Cornerstone of Prostate Cancer Management, While LHRH Antagonists Deliver Both Clinical Efficacy and Quality of Life

In this edition of Clear Horizons, Comprehensive Urologic Care, Professor Xin Yao from Tianjin Medical University Cancer Institute and Hospital discusses the mechanistic and clinical differences between LHRH agonists and antagonists, as well as practical strategies for managing ADT-related adverse events to maximize both treatment efficacy and patient quality of life.