IOncology

Muscle-invasive bladder cancer (MIBC) presents unique challenges due to its aggressive nature and the complexity of its treatment. At ESMO Asia 2024, Dr. Brigida Maiorano shared valuable insights into evolving strategies, including bladder-preserving approaches, novel clinical trial designs, and the latest advances in targeted therapies. In this exclusive interview with Oncology Frontier, Dr. Maiorano discusses current standards, promising clinical results, and her vision for improving outcomes in MIBC.

With the development of immune checkpoint inhibitors (ICIs) and the widespread application of immunotherapy, the treatment paradigm for driver mutation-negative lung cancer has been fundamentally transformed. Multiple studies have demonstrated that radiotherapy (RT) can regulate both local and systemic immune responses, triggering anti-tumor immune effects. As a result, the immunomodulatory properties of RT and its synergistic effects when combined with immunotherapy have garnered significant attention within the medical community.

Investigator-initiated trials (IITs) refer to clinical research initiated by investigators, conducted in healthcare institutions, and aimed at studying disease diagnosis, treatment, rehabilitation, prognosis, etiology, prevention, and health maintenance. Unlike industry-sponsored trials, IITs are not intended for drug or medical device registration. In recent years, IITs have become an essential part of clinical research, providing critical data and insights for drug development in China. However, the rapid increase in IITs has underscored the need for enhanced management and standardization.

The 2024 Chinese Congress on Holistic Integrative Oncology (CCHIO) concluded successfully on November 17. Following the strategic framework of "collaborative integration" in disciplinary development, the conference established dedicated sessions on tumor rehabilitation, health education, cancer prevention, and screening. These sessions offered comprehensive and multidimensional insights into new perspectives, technologies, and concepts for the full-cycle management of oncology, spanning prevention, screening, diagnosis, treatment, and rehabilitation.

At the 2024 Chinese Congress on Holistic Integrative Oncology (CCHIO), Dr. Xinping Cao from Sun Yat-sen University Cancer Center presented a comprehensive lecture titled “Advances in Systemic Therapy for Cervical Cancer.” Below is a summary of the key highlights.

Breast cancer not only threatens patients' lives but also imposes a heavy psychological burden on women. As the number of breast cancer cases continues to rise, its rehabilitation is gaining increasing attention from society. How to effectively promote comprehensive recovery for breast cancer patients has become an important issue in the medical field. During the 2024 Chinese Congress on Holistic Integrative Oncology (CCHIO), Oncology Frontier interviewed Dr. Hong Liu, Chair of the Breast Cancer Integrated Rehabilitation Committee of the Chinese Anti-Cancer Association and a leading expert at Tianjin Medical University Cancer Institute and Hospital. Professor Liu discussed the importance of psychological rehabilitation for breast cancer patients, prospects for the development of the rehabilitation field, applications of new technologies and methods, and the significance of multidisciplinary collaboration. Drawing on her extensive clinical experience, Professor Liu shed light on new trends in breast cancer rehabilitation, offering hope for patients.

On November 23rd, Dr. Tianshu Liu's team from Zhongshan Hospital published a study titled "Trilaciclib prior to FOLFOXIRI/bevacizumab for patients with untreated metastatic colorectal cancer: phase 3 PRESERVE 1 trial" in JNCI Cancer Spectrum(IF=3.4). The PRESERVE 1 trial sheds light on trilaciclib's potential to reduce chemotherapy-related toxicity in mCRC. While its efficacy in mitigating myelosuppression is evident, the antitumor results are concerning. Further studies are needed to explore the balance between toxicity reduction and efficacy, and to determine trilaciclib's optimal use in cancer treatment.

EGFR mutations are among the most common genetic abnormalities in non-squamous non-small cell lung cancer (NSCLC), and EGFR-TKIs have become the standard first-line treatment for advanced EGFR-mutant NSCLC. Despite significant advancements across three generations of EGFR-TKIs, resistance remains unavoidable. Post-resistance treatment options for EGFR-TKI patients, particularly those facing complex third-generation resistance mechanisms, are limited.

At the 2024 CCHIO Lung Tumor Integrated Rehabilitation Session, Dr. Dingzhi Huang from Tianjin Medical University Cancer Institute and Hospital delivered a presentation titled “Advances in SCLC Treatment.” Below is a comprehensive summary of the key highlights.