Breakthrough in Clinical Treatment of Chronic Drug-Induced Liver Injury: Optimizing Steroid Regimen and Indications – A Voice from AASLD China

Breakthrough in Clinical Treatment of Chronic Drug-Induced Liver Injury: Optimizing Steroid Regimen and Indications – A Voice from AASLD China

Recently, the Liver Disease Department and Pathology Department at the Fifth Medical Center of the People's Liberation Army General Hospital (formerly the PLA Third O2 Hospital) collaborated to achieve a new breakthrough in the clinical treatment of Chronic Drug-Induced Liver Injury (DILI). The research teams, led by Dr. Zhengsheng Zou, Jingmin Zhao, and Dong Ji, previously pioneered the establishment of a 48-week Steroid Stepwise Reduction (48w-SSR) treatment plan for chronic recurrent DILI, demonstrating its efficacy and safety through rigorous Randomized Controlled Trials (RCTs). The results were published in the prestigious journal Alimentary Pharmacology & Therapeutics (a TOP journal in the 1st area of the Chinese Academy of Sciences).
Doctor Thomas Reiberger: Hotly Debated Issues on the Use of Non-Selective Beta-Blockers (NSBBs) in the Treatment of Cirrhosis

Doctor Thomas Reiberger: Hotly Debated Issues on the Use of Non-Selective Beta-Blockers (NSBBs) in the Treatment of Cirrhosis

🔍 Exploring the Complexities of Cirrhosis Treatment: Insights from Dr. Thomas Reiberger Welcome to the latest feature from Hepatology Digest, where we delve into the nuanced world of liver health. In our upcoming article, we're excited to present the esteemed Dr. Thomas Reiberger, a leading figure in hepatology, known for his extensive research and clinical expertise. Dr. Reiberger brings a wealth of knowledge to the table, particularly in the controversial use of Non-Selective Beta-Blockers (NSBBs) for treating cirrhosis. Join us as we navigate the complexities of this treatment, examining its benefits, challenges, and the heated debates it sparks in the medical community. Stay tuned for an enlightening journey through the lens of a distinguished expert. 🔗 Stay connected with Hepatology Digest for cutting-edge insights and discussions.
Dr. Lai Wei’s Team at Tsinghua Chang Gung: Latest Developments in the Nationwide “MAFLD Epidemiological Survey Research Project” on Health Check-up

Dr. Lai Wei’s Team at Tsinghua Chang Gung: Latest Developments in the Nationwide “MAFLD Epidemiological Survey Research Project” on Health Check-up

In 2020, the international expert consensus on metabolic dysfunction-associated fatty liver disease (MAFLD) proposed a new definition, suggesting MAFLD as a more appropriate term to describe liver diseases related to metabolic dysfunction. According to the latest standards, patients with liver fat deposition meet at least one of the following three criteria: overweight or obesity, type 2 diabetes, or the presence of metabolic dysfunction (if their weight is normal). To comprehensively understand the current status of MAFLD in China, promote awareness among medical professionals and patients, and increase the diagnosis rate of the disease, in 2022, the National Health Examination Population "MAFLD Epidemiological Survey Research Project," led by Dr. Lai Wei of Tsinghua University Affiliated Beijing Tsinghua Chang Gung Hospital and co-initiated by the China Liver Health Promotion Center, was successfully launched. The two latest research findings from the project have been included in the 2023 Annual Meeting of the American Association for the Study of Liver Disease (AASLD). Dr. Lai Wei has been invited by the Hepatology Digest to provide a detailed introduction to these two studies, the content of which is shared below.
AASLD Voice of China | Dr. Zhenhuan Cao’s Team: The Impact of Hepatic Steatosis on Antiviral Therapy in Patients with Chronic Hepatitis B

AASLD Voice of China | Dr. Zhenhuan Cao’s Team: The Impact of Hepatic Steatosis on Antiviral Therapy in Patients with Chronic Hepatitis B

From November 10th to 14th, 2023, the annual highlight in the field of hepatology—the American Association for the Study of Liver Diseases (AASLD) Annual Meeting 2023 was grandly held in Boston, USA. Dr. Zhenhuan Cao from Beijing You'an Hospital, Capital Medical University, as the corresponding author, presented a research abstract at the conference, revealing the influence of hepatic steatosis on the efficacy of antiviral therapy in patients with chronic hepatitis B (CHB). The results suggest that hepatic steatosis has no significant impact on the effectiveness of nucleos(t)ide analogs (NAs) and pegylated interferon (PEG-IFN) treatment [1]. Hepatology Digest reports on this, and the relevant content is shared below.
AASLD Review | New Therapies for Hepatitis B: Vebicorvir, Selgantolimod, Bepirovirsen, Therapeutic Vaccines, and More

AASLD Review | New Therapies for Hepatitis B: Vebicorvir, Selgantolimod, Bepirovirsen, Therapeutic Vaccines, and More

Currently, some patients with chronic hepatitis B (CHB) can achieve clinical cure through interferon-based antiviral treatment. To pursue clinical cure for a larger population, there is a flurry of activity in the development of new drugs. Six studies on new therapies for hepatitis B were selected for presentation at the 2023 American Association for the Study of Liver Diseases (AASLD) Annual Meeting, to be discussed in the "Hepatitis B: New Therapies for HBV and HDV" session. Hepatology Digest has compiled this information for interested readers, and the session is scheduled for online access on November 12th at 8:30 AM local time.
AASLD Hot Topic | Dr. Zhihong Liu of Southern Hospital: Hepatitis B Expanded Treatment, Simplified Treatment, and Progress in Functional Cure Drugs Deserve Attention

AASLD Hot Topic | Dr. Zhihong Liu of Southern Hospital: Hepatitis B Expanded Treatment, Simplified Treatment, and Progress in Functional Cure Drugs Deserve Attention

The AASLD (American Association for the Study of Liver Diseases) 2023 conference was held in Boston, USA, from November 10th to 14th, marking a significant event in the field of hepatology. Hepatology Digest's reporting team was fortunate to invite Dr. Zhihong Liu from the Department of Infectious Diseases and Hepatology at Southern Hospital of Southern Medical University to share insights from the AASLD and discuss the work presented by his team at the conference, along with their learning experiences.
AASLD Interview | Professor Wai-Kay Seto’s Team: Presentation of Five Achievements in Predicting Clinical Cure of Hepatitis B and Post-operative Recurrence of Liver Cancer, and Commentary on Liver Disease Research Trends

AASLD Interview | Professor Wai-Kay Seto’s Team: Presentation of Five Achievements in Predicting Clinical Cure of Hepatitis B and Post-operative Recurrence of Liver Cancer, and Commentary on Liver Disease Research Trends

The 74th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD 2023) has just concluded in Boston, USA. The team led by Professor Wai-Kay Seto from the University of Hong Kong focused on five research outcomes in the areas of mother-to-child transmission blockage and clinical cure of Hepatitis B, clearance of Hepatitis C, post-operative recurrence of liver cancer, and post-liver transplant management. These outcomes were presented at the meeting, with two of them being shared in the form of oral presentations. Professor Seto's team has been committed to the clinical management and scientific research of chronic liver diseases, achieving fruitful results. Hepatology Digest invited the team's principal researchers to interpret the findings and comment on the trends in liver disease research and share their experiences at the conference. The interview video is shared below.
AASLD Interview | Professor Bernd Schnabl: Delving into the “Gut-Liver Axis,” Decoding the Role of Gut Microbiota in the Diagnosis and Treatment of Autoimmune Liver Diseases

AASLD Interview | Professor Bernd Schnabl: Delving into the “Gut-Liver Axis,” Decoding the Role of Gut Microbiota in the Diagnosis and Treatment of Autoimmune Liver Diseases

The gut microbiome, a complex ecosystem within the human intestinal tract, has a broad impact on physiological functions. Gut microbiome imbalance has become one of the most critical environmental factors in the onset of chronic inflammatory diseases. The liver is one of the first identified targets of autoimmune attack. In recent years, with deeper research into the gut microbiome, the relationship between gut microbiota and liver diseases has gained increasing attention. Studies have found that gut microbiota might play a role in the development and progression of autoimmune liver diseases, making the treatment of gut microbiota imbalance a potential key target.