2026 Northern Breast Cancer Forum丨Prof. Yunjiang Liu: From Endocrine Therapy to Precision Targeted Therapy — Milestones in HR-Positive Breast Cancer
Hormone receptor (HR)-positive breast cancer accounts for approximately 70% of all breast cancer cases. From the early exploration of ovarian ablation more than a century ago, to tamoxifen ushering in the era of endocrine therapy, and then to CDK4/6 inhibitor-based combinations reshaping the treatment landscape of advanced disease, each major therapeutic breakthrough has profoundly altered the survival trajectory of patients. However, treatment resistance remains a major clinical challenge. The discovery of resistance mechanisms such as PI3K/AKT/mTOR pathway alterations and ESR1 mutations has subsequently driven the development of increasingly precise targeted strategies. The 2026 Northern Breast Cancer Forum was successfully held in Qingdao from July 25 to 26. During the meeting, Oncology Frontier interviewed Prof. Yunjiang Liu from the Fourth Hospital of Hebei Medical University, who provided an in-depth overview of the major milestones in HR-positive breast cancer treatment, precision strategies following CDK4/6 inhibitor resistance, and the new opportunities created by domestically developed innovative therapies.









