EAU26 | Professor Yi-Jun Shen on the HERO Study: Disitamab Vedotin Plus BCG Shows Promise in HR-NMIBC 

EAU26 | Professor Yi-Jun Shen on the HERO Study: Disitamab Vedotin Plus BCG Shows Promise in HR-NMIBC 

Non–muscle-invasive bladder cancer (NMIBC) carries a substantial risk of postoperative recurrence, particularly in high-risk and very high-risk patients, where the 5-year recurrence rate can exceed 50%. In recent years, beyond traditional Bacillus Calmette–Guérin (BCG) intravesical therapy, the emergence of immune checkpoint inhibitors (ICIs) and antibody–drug conjugates (ADCs) has provided new therapeutic options to reduce recurrence risk in high-risk NMIBC.
ASCO GU On-site Report | Dr. Aly-Khan A. Lalani Presents CYTOSHRINK Trial Results: Early Dual Immunotherapy Combined with SBRT Shows Promise for Durable Responses in Advanced Renal Cancer

ASCO GU On-site Report | Dr. Aly-Khan A. Lalani Presents CYTOSHRINK Trial Results: Early Dual Immunotherapy Combined with SBRT Shows Promise for Durable Responses in Advanced Renal Cancer

The 2026 American Society of Clinical Oncology Genitourinary Cancers Symposium (ASCO GU 2026) has successfully concluded. Numerous landmark studies in genitourinary oncology were presented, providing key evidence to inform and refine clinical practice. Among them, the phase II randomized CYTOSHRINK trial, focusing on treatment-naïve advanced renal cell carcinoma, reported its latest findings, offering important insights into the integration of immunotherapy with radiotherapy. We invited Professor Aly-Khan A. Lalani from the Juravinski Cancer Centre at McMaster University, Canada, to discuss the study design, clinical implications, and future directions in the field.