Month: June 2025

Acute myeloid leukemia (AML) is a highly heterogeneous clonal malignancy, accounting for approximately 15–20% of pediatric leukemia cases. The current standard first-line induction regimen, known as "3+7," achieves complete remission (CR) rates of approximately 70%. However, about 25% of pediatric patients eventually progress to relapsed/refractory AML (R/R AML), associated with poor prognosis.

Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by antibody-mediated platelet destruction and impaired platelet production, resulting in an increased risk of bleeding. In children, the annual incidence of ITP is approximately 1.9 to 6.4 per 100,000, making it the most common cause of acquired thrombocytopenia in pediatric patients. While most children achieve spontaneous remission either without treatment or following initial therapy, a subset of patients experience recurrent relapses requiring second-line interventions, including rituximab, thrombopoietin receptor agonists (TPO-RAs), splenectomy, and immunosuppressive agents. Due to the lack of prospective clinical trial data in children, selecting optimal second-line therapies remains a considerable clinical challenge.

In recent years, growing understanding of the structural and immune microenvironmental features of hepatocellular carcinoma (HCC) has placed immunotherapy at the forefront of HCC research and treatment. The emergence of immune checkpoint inhibitors (ICIs) and adoptive cell therapy (ACT) has opened new avenues of hope for patients with HCC. ACT, in particular, is a promising approach that involves the infusion of ex vivo activated and expanded autologous or allogeneic immune effector cells, and has shown potential in the treatment of infections, autoimmune disorders, and malignancies.

Hepatocellular carcinoma (HCC) is a major global health burden and a leading cause of cancer-related mortality. Curative hepatectomy is often not feasible due to advanced disease or insufficient liver function. Transarterial chemoembolization (TACE) remains the standard treatment for patients in the intermediate stage, and in some guidelines, even for advanced stages. However, the landscape has evolved with the introduction of tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs). While these therapies have shown clinical efficacy individually or in dual combinations, the benefit of combining all three modalities—TACE, TKIs, and ICIs—as a "triple conversion therapy" had not been validated in large, real-world cohorts until the GUIDANCE001 study.

Editor’s Note At the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting, the ANCHOR study, led by Professor Kefeng Ding from the Second Affiliated Hospital of Zhejiang University School of Medicine, was presented as a Late-Breaking Abstract (LBA), marking a significant breakthrough in the treatment landscape of advanced colorectal cancer.

Editor’s Note At the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting, three high-impact studies targeting KRAS G12C-mutant colorectal cancer (CRC) revealed groundbreaking progress in precision oncology. KRAS G12C is a notoriously difficult-to-treat molecular subtype of CRC, historically plagued by limited therapeutic options. However, the presentation of data from the CodeBreaK 101 study, a Phase I/II trial of olomorasib combined with cetuximab, and the KANDLELIT-001 trial has brought new hope to the field.

Editor’s Note: In recent years, novel therapies targeting folate receptor alpha (FRα)—such as mirvetuximab soravtansine-gynx—have offered new hope for patients with FRα-high, platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal…

Editor’s Note: Since the PACIFIC study established sequential immunotherapy following chemoradiotherapy as the standard of care for unresectable stage III non-small cell lung cancer (NSCLC), the global focus has shifted…

Editor’s Note: A deep understanding of the dynamic changes within the tumor microenvironment is crucial to accurately assess treatment response and disease progression in cancer patients. At the 2025 ASCO…