Professor David Curtis Elaborates on the Breakthrough Results of the ALLG BM12 CAST Study丨EHA 2025

Professor David Curtis Elaborates on the Breakthrough Results of the ALLG BM12 CAST Study丨EHA 2025

The 30th European Hematology Association (EHA) Annual Meeting 2025 was grandly held in Milan, Italy, gathering top experts from the global hematology community to discuss and share the latest research progress and cutting-edge technologies in the field. During the Plenary Session, Professor David Curtis from the Australasian Leukaemia and Lymphoma Group (ALLG), on behalf of his team, announced the first results of the ALLG BM12 CAST clinical trial. This Phase III randomized controlled trial, focusing on peripheral blood stem cell transplantation from matched sibling donors, provides powerful "practice-changing" evidence to solve the challenge of Graft-versus-Host Disease (GVHD) prophylaxis, a problem that has puzzled clinicians for nearly forty years, sparking significant interest and heated discussion among attendees.
Subverting Traditional Concepts: CLL Does Not Originate from a Single Clone; Multiple Independent Minor Clones Plant the “Seeds” Early On丨EHA 2025

Subverting Traditional Concepts: CLL Does Not Originate from a Single Clone; Multiple Independent Minor Clones Plant the “Seeds” Early On丨EHA 2025

The 2025 European Hematology Association (EHA) Annual Meeting was grandly held both online and in person, gathering top experts and cutting-edge research from the global hematology community. At this conference, a revolutionary study on the origin of Chronic Lymphocytic Leukemia (CLL) attracted widespread attention. A research team from Spain, using multi-omics single-cell sequencing technologies, revealed that CLL does not, as traditionally believed, originate from a single clone. Instead, in some patients, multiple independent minor clones with the biological characteristics of CLL exist, having emerged and begun to evolve decades before the disease is diagnosed. This discovery not only profoundly reshapes our understanding of CLL pathogenesis but also provides a completely new theoretical basis for future early diagnosis and intervention strategies.
Professor Jakob Kather Elaborates on the Evolution and Future Prospects of AI in Hematologic Oncology丨EHA 2025

Professor Jakob Kather Elaborates on the Evolution and Future Prospects of AI in Hematologic Oncology丨EHA 2025

The 2025 European Hematology Association (EHA) Annual Meeting was held in a hybrid format, both online and in-person, gathering top experts and scholars from the global hematology community. The conference focused on the deep integration of cutting-edge technology and clinical practice, with the application of Artificial Intelligence (AI) being one of the core topics. Professor Jakob Nikolas Kather from the Technische Universität Dresden, Germany, was invited to deliver a keynote speech titled "Artificial Intelligence in Hematology: Opportunities, Pitfalls, and How to Bring It into Clinical Practice." He systematically described the revolutionary changes in AI technology from its early explorations to the current era of large models. He particularly highlighted his team's pioneering research on empowering Tumor Board decision-making with AI Agents, charting a course for the future development of AI in hematologic oncology.
Professor John Mascarenhas Details Breakthrough Safety and Efficacy Data of INCA33989 in Patients with ET丨EHA 2025

Professor John Mascarenhas Details Breakthrough Safety and Efficacy Data of INCA33989 in Patients with ET丨EHA 2025

The 2025 European Hematology Association (EHA) Annual Meeting was recently held, bringing together top global experts in the field of hematologic malignancies to discuss the latest research findings and future directions. In the highly anticipated "Late-Breaking Abstract" session, Professor John Mascarenhas from the Icahn School of Medicine at Mount Sinai presented clinical study data on INCA33989, a novel, first-in-class monoclonal antibody specific to mutant calreticulin (CALR). The study results showed that INCA33989 demonstrated excellent safety and revolutionary therapeutic potential in previously treated patients with Essential Thrombocythemia (ET), with the potential to change the current treatment landscape