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Safety and activity of an engineered, liver-tropic adeno-associated virus vector expressing a hyperactive Padua factor IX administered with prophylactic glucocorticoids in patients with haemophilia B: a single-centre, single-arm, phase 1, pilot trial
Hemophilia B is a monogenic inherited bleeding disorder caused by a mutation in the F9 gene, resulting in lifelong excessive bleeding, typically occurring in joints and muscles, leading to arthropathy.…
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Revolutionizing Multiple Myeloma Treatment: FCRL5-Directed CAR-T Cells Enhanced with IL-15 Show Promising Antitumor Activity
In January 2024, a study led by Professor Ting Niu from West China Hospital, Sichuan University was published in the international academic journal ——Signal Transduction And Targeted Therapy (IF=38.104). The title of the study is “Fc receptor-like 5 (FCRL5)-directed CAR-T cells exhibit antitumor activity against multiple myeloma”. This study sheds light on the promising potential…
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Mutation landscape of normal karyotype myelodysplastic syndromes and their prognostic impact
Myelodysplastic syndromes (MDS) encompass a heterogeneous group of hematological disorders characterized by dysplastic changes in the bone marrow, ineffective hematopoiesis, and a risk of progression to acute myeloid leukemia (AML).…
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Low cholesterol levels are associated with increasing risk of plasma cell neoplasm: A UK biobank cohort study
In November 2023, a study led by Professor Ting Niu from West China Hospital, Sichuan University was published in the international academic journal ——Cancer Medicine. The title of the study…
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Time-Dependent Effects of Early-Onset Epstein-Barr Viremia on Adult Acute Leukemia Patients Following Allo-HSCT with ATG-Containing MAC Regimen
In July 2021, a study led by Professor Zhengzheng Fu from the First Affiliated Hospital of Soochow University was published in the international academic journal ——Annals of Hematology. The title…
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ASCO-GU Interview | Dr. Yige Bao Shares Progress in PARPi Precision Treatment of Prostate Cancer and His Team’s Research on Neoadjuvant Therapy for UTUC
Oncology Frontier: Can you share with us the research your team submitted to this ASCO-GU meeting? Dr. Yige Bao: At this ASCO-GU meeting, I represented the urology team led by…
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Imatinib compared with second-generation tyrosine kinase inhibitors in persons with chronic myeloid leukemia presenting in accelerated phase
In July 2023, a study led by Professor Qian Jiang from Peking University Institute of Hematology was published in the international academic journal ——American Journal of Hematology (IF=12.8). The title…
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External Validation of Predictive Scoring Systems for Molecular Responses in Chronic Myeloid Leukemia Receiving Imatinib Therapy
In September 2023, a study led by Professor Qian Jiang from Peking University Institute of Hematology was published in the international academic journal ——Leukemia(IF=11.4). The title of the study is…
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